Chakraborty Sajib, Rahman Taibur
University of Dhaka, Dhaka, Bangladesh.
Ecancermedicalscience. 2012 Nov 14;6:ed16. doi: 10.3332/ecancer.2012.ed16. eCollection 2012.
Cancer is clearly the most deadly disease in the developed world as one in three people develop cancer during their lifetime. The cure for cancer is like the Holy Grail since most of the existing treatments are not effective enough to provide full protection from this disease. In recent years the burgeoning of sophisticated genomic, proteomic and bioinformatics techniques has made it possible for us to get a glimpse of the intricate interplay of numerous cellular genes and regulatory genetic elements that are responsible for the manifestation of cancerous phenotypes. With the use of modern genomic technologies we are now beginning to understand the enormous complexity of cancer. However there are few success stories as far as the treatment of cancer is concerned. For instance the treatments of leukemia and lymphoma have been established and proved to be satisfactory. Despite occasional successes the treatment for most cancers is still a long way from reality. In this editorial, we have addressed several reasons for the difficulties in cancer treatment.
在发达国家，癌症显然是最致命的疾病，因为三分之一的人在其一生中会患上癌症。癌症的治愈方法犹如圣杯，因为现有的大多数治疗方法都不够有效，无法提供对这种疾病的全面防护。近年来，先进的基因组学、蛋白质组学和生物信息学技术的蓬勃发展，使我们得以瞥见众多细胞基因和调控遗传元件之间复杂的相互作用，正是这些相互作用导致了癌性表型的出现。借助现代基因组技术，我们现在开始理解癌症的巨大复杂性。然而，就癌症治疗而言，成功案例寥寥无几。例如，白血病和淋巴瘤的治疗方法已经确立并被证明是令人满意的。尽管偶尔有成功的案例，但大多数癌症的治疗距离实际成效仍有很长的路要走。在这篇社论中，我们探讨了癌症治疗困难的几个原因。
