Field L L
Department of Pediatrics, University of Calgary, Canada.
Genet Epidemiol. 1989;6(1):101-6. doi: 10.1002/gepi.1370060119.
Analysis of HLA haplotypes occurring in more than one, only one, or no diabetics in GAW5 multiplex insulin-dependent diabetes mellitus (IDDM) families suggested: 1) DR3, DR4, DRw6, and DRw8 are positively associated, and DR2 is negatively associated, with IDDM; 2) DR4 haplotypes are more diabetogenic than DR3 haplotypes; some DR3 haplotypes lacking B8/B18 are more diabetogenic than those carrying B8/B18; DR3 haplotypes with DR beta TaqI bands [2,5,10/11] are more diabetogenic than those without; DR4 haplotypes that carry DQw3.2 are more diabetogenic than those that do not; some DR2 haplotypes are diabetogenic rather than protective. Analysis of DR3 and DR4 transmission from DR3/X and DR4wX (X not equal to 3,4) healthy parents suggested: 3) no distortion of transmission to healthy children and 4) mothers transmit DR4 (and perhaps DR3) less often than fathers to diabetic children. Analysis of INS, GM, and HLA haplotype sharing in affected sib pairs suggested: 5) random segregation of INS haplotypes and 6) a tendency to increased sharing of GM haplotypes in affected sib pairs who were HLA-identical and DR3/4, compared with pairs who were not.
对GAW5中多个、仅一个或无糖尿病患者的多重胰岛素依赖型糖尿病（IDDM）家系中出现的HLA单倍型分析表明：1）DR3、DR4、DRw6和DRw8与IDDM呈正相关，而DR2与IDDM呈负相关；2）DR4单倍型比DR3单倍型更具糖尿病致病性；一些缺乏B8/B18的DR3单倍型比携带B8/B18的更具糖尿病致病性；具有DRβTaqI条带[2,5,10/11]的DR3单倍型比没有的更具糖尿病致病性；携带DQw3.2的DR4单倍型比不携带的更具糖尿病致病性；一些DR2单倍型具有糖尿病致病性而非保护性。对来自DR3/X和DR4wX（X不等于3,4）健康父母的DR3和DR4传递分析表明：3）向健康儿童的传递无畸变，以及4）母亲向糖尿病儿童传递DR4（可能还有DR3）的频率低于父亲。对患病同胞对中INS、GM和HLA单倍型共享情况的分析表明：5）INS单倍型随机分离，以及6）与非HLA相同且非DR3/4的患病同胞对相比，HLA相同且为DR3/4的患病同胞对中GM单倍型共享增加的趋势。
