真菌中的双萘并-γ-吡喃酮及其生物活性。
Bis-naphtho-γ-pyrones from fungi and their bioactivities.
机构信息
MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.
Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
出版信息
Molecules. 2014 May 30;19(6):7169-88. doi: 10.3390/molecules19067169.
Abstract
Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.
摘要
双萘并-γ-吡喃酮是一类重要的芳香聚酮类化合物，来源于真菌。它们具有多种生物活性，包括细胞毒性、抗肿瘤、抗菌、酪氨酸激酶和 HIV-1 整合酶抑制活性，这表明它们在医学和农业领域具有潜在的应用前景。在过去的几十年中，已经报道了至少 59 种来自真菌的双萘并-γ-吡喃酮。本综述旨在简要总结它们的存在、生物合成、结构以及生物活性。还讨论了双萘并-γ-吡喃酮的合成、生产以及在医学和农业方面的应用的一些考虑因素。
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