Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, People's Republic of China.
Arch Pharm Res. 2014 May;37(5):575-9. doi: 10.1007/s12272-013-0206-3. Epub 2013 Aug 2.
Isochaetomium A2 (1), a new bis(naphthodihydropyran-4-one), along with chaetochromins A (2) and B (3), was isolated from the solid-state fermented rice culture of Chaetomium microcephalum. The structure of compound 1 was elucidated on the basis of 1D and 2D NMR spectral data, and the relative configuration was confirmed by CD spectrum. Compounds 1-3 possessed significant antimicrobial activity against Escherichia coli 1.044, Staphylococcus aureus 1.252, and Bacillus subtilis 1.079. Moreover, compounds 1-3 showed obvious inhibitory effects on mouse spleen cell proliferation with successive IC50 values of 0.52, 0.19, and 0.24 μM.
从米曲霉固态发酵培养物中分离得到一个新的双（萘并二氢吡喃-4-酮）化合物 Isochaetomium A2(1)，以及 chaetochromins A(2)和 B(3)。根据 1D 和 2D NMR 光谱数据阐明了化合物 1 的结构，并通过 CD 光谱确定了其相对构型。化合物 1-3 对大肠杆菌 1.044、金黄色葡萄球菌 1.252 和枯草芽孢杆菌 1.079 具有显著的抗菌活性。此外，化合物 1-3 对小鼠脾细胞增殖具有明显的抑制作用，其连续 IC50 值分别为 0.52、0.19 和 0.24 μM。
