2007年至2016年：真菌聚酮化合物成果丰硕的十年——抗菌活性、化学分类学与化学多样性

A fruitful decade for fungal polyketides from 2007 to 2016: antimicrobial activity, chemotaxonomy and chemodiversity.

作者信息

Hussain Hidayat, Al-Sadi Abdullah M, Schulz Barbara, Steinert Michael, Khan Ajmal, Green Ivan R, Ahmed Ishtiaq

机构信息

UoN Chair of Oman's Medicinal Plants & Marine Natural Products, University of Nizwa, PO Box 33, Birkat Al Mauz, Nizwa 616, Sultanate of Oman.

Department of Crop Sciences, College of Agricultural & Marine Sciences, Sultan Qaboos University, PO Box 34, Al Khod 123, Oman.

出版信息

Future Med Chem. 2017 Sep;9(14):1631-1648. doi: 10.4155/fmc-2017-0028. Epub 2017 Sep 8.

DOI:10.4155/fmc-2017-0028

PMID:28884584

Abstract

The last three decades have shown that the fungi can be 'biofactories' of novel, bioactive secondary metabolites that produce numerous natural products with novel skeletons and biological activities. Particularly in the last 10 years, large numbers of antimicrobial fungal secondary metabolites have been discovered. This review provides an overview of key, defining developments of the last 10 years regarding the discovery of antimicrobial activity, chemotaxonomy and chemodiversity of fungal polyketides.

摘要

过去三十年表明，真菌可以成为新型生物活性次级代谢产物的“生物工厂”，这些次级代谢产物能产生众多具有新颖骨架和生物活性的天然产物。特别是在过去十年中，已发现大量具有抗菌活性的真菌次级代谢产物。本综述概述了过去十年在真菌聚酮化合物的抗菌活性发现、化学分类学和化学多样性方面的关键决定性进展。