Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Arch Pharm Res. 2013 Jun;36(6):739-44. doi: 10.1007/s12272-013-0077-7. Epub 2013 Mar 6.
In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.
在我们对抗结核药物的筛选中，从海绵来源的真菌玫烟色棒束孢 mxh-99 的提取物中分离得到了五个萘并γ-吡喃酮，包括两个新的萘并γ-吡喃酮糖苷，靛红 G 和 H（1 和 2），以及两个二苯醚。它们的结构是基于化学和光谱证据确定的。所有化合物的抗结核活性均针对分枝杆菌进行了评估。已知的异麦角醇 B2（6）和麦角甾醇 D（7）表现出最高的活性，MIC 为 50.0 μg/mL。
