Sanches Marsal, Scott-Gurnell Kathy, Patel Anita, Caetano Sheila C, Zunta-Soares Giovana B, Hatch John P, Olvera Rene, Swann Alan C, Soares Jair C
UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Compr Psychiatry. 2014 Aug;55(6):1337-41. doi: 10.1016/j.comppsych.2014.04.018. Epub 2014 May 2.
Increased impulsivity seems to be present across all phases of bipolar disorder (BD). Impulsivity may therefore represent an endophenotype for BD, if it is also found among normal individuals at high genetic risk for mood disorders. In this study, we assessed impulsivity across four different groups of children and adolescents: patients with BD, major depressive disorder (MDD) patients, unaffected offspring of bipolar parents (UO), and healthy controls (HC).
52 patients with BD, 31 with MDD, 20 UO, and 45 HC completed the Barratt Impulsiveness Scale (BIS-11), an instrument designed to measure trait impulsivity.
UO displayed significantly higher total BIS-11 impulsivity scores than HC (p=0.02) but lower scores than BD patients (F=27.12, p<0.01). Multiple comparison analysis revealed higher BIS-11 total scores among BD patients when compared to HC (p<0.01) and UO (p<0.01). MDD patients had higher BIS-11 scores when compared to HC (p<0.01). Differences between MDD patients and UO, as well as between MDD and BD patients, were not statistically significant.
Our findings suggest that trait impulsivity is increased among children and adolescents with mood disorders, as well as in unaffected individuals at high genetic risk for BD.
冲动性增加似乎在双相情感障碍（BD）的各个阶段均存在。因此，如果在患情绪障碍遗传风险高的正常个体中也发现冲动性，那么它可能代表BD的一种内表型。在本研究中，我们评估了四组不同儿童和青少年的冲动性：BD患者、重度抑郁症（MDD）患者、双相情感障碍患者的未患病后代（UO）以及健康对照（HC）。
52例BD患者、31例MDD患者、20例UO以及45例HC完成了巴雷特冲动性量表（BIS - 11），这是一种用于测量特质冲动性的工具。
UO的BIS - 11冲动性总分显著高于HC（p = 0.02），但低于BD患者（F = 27.12，p < 0.01）。多重比较分析显示，与HC（p < 0.01）和UO（p < 0.01）相比，BD患者的BIS - 11总分更高。与HC相比，MDD患者的BIS - 11得分更高（p < 0.01）。MDD患者与UO之间以及MDD与BD患者之间的差异无统计学意义。
我们的研究结果表明，情绪障碍儿童和青少年以及BD遗传风险高的未患病个体的特质冲动性增加。
