精神障碍患者全因和自杀死亡率的风险：荟萃分析综述。
Risks of all-cause and suicide mortality in mental disorders: a meta-review.
机构信息
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
出版信息
World Psychiatry. 2014 Jun;13(2):153-60. doi: 10.1002/wps.20128.
A meta-review, or review of systematic reviews, was conducted to explore the risks of all-cause and suicide mortality in major mental disorders. A systematic search generated 407 relevant reviews, of which 20 reported mortality risks in 20 different mental disorders and included over 1.7 million patients and over a quarter of a million deaths. All disorders had an increased risk of all-cause mortality compared with the general population, and many had mortality risks larger than or comparable to heavy smoking. Those with the highest all-cause mortality ratios were substance use disorders and anorexia nervosa. These higher mortality risks translate into substantial (10-20 years) reductions in life expectancy. Borderline personality disorder, anorexia nervosa, depression and bipolar disorder had the highest suicide risks. Notable gaps were identified in the review literature, and the quality of the included reviews was typically low. The excess risks of mortality and suicide in all mental disorders justify a higher priority for the research, prevention, and treatment of the determinants of premature death in psychiatric patients.
元分析综述，或系统性综述的综述，旨在探究主要精神障碍患者的全因死亡率和自杀死亡率风险。系统检索生成了 407 篇相关综述，其中 20 篇综述报告了 20 种不同精神障碍的死亡率风险，纳入了超过 170 万名患者和超过 25 万例死亡。与普通人群相比，所有精神障碍患者的全因死亡率均升高，其中许多精神障碍的死亡率风险大于或与重度吸烟相当。全因死亡率比值最高的是物质使用障碍和神经性厌食症。这些更高的死亡率风险导致预期寿命显著（10-20 年）缩短。边缘型人格障碍、神经性厌食症、抑郁症和双相情感障碍的自杀风险最高。在综述文献中发现了明显的差距，并且纳入的综述质量通常较低。所有精神障碍患者的死亡和自杀风险过高，这证明需要优先对精神科患者早逝的决定因素进行研究、预防和治疗。
Zotero 插件