Zhang Shihui, Xu Tian, Peng Yanbo, Peng Hao, Wang Aili, Wang Guiyan, Wang Dali, Zhang Yonghong
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China; Department of Food Sanitation, Suzhou Food and Drug Administration, Suzhou, Jiangsu 215007, China.
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
Chin Med J (Engl). 2014;127(11):2016-20.
Many studies have suggested that C-reactive protein (CRP) and blood lipids are associated with hypertension and cardiovascular disease (CVD). However, few studies discussed the combined action of CRP and blood lipids on the risk of hypertension and prehypertension. This study aimed to investigate the combined action of CRP and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults from Inner Mongolia, China.
The systolic and diastolic blood pressure, height, weight and waist circumference were measured and factors such as smoking, alcohol intake, family history of hypertension, etc., were investigated and CRP, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) were tested for 2 534 Mongolian adults aged ≥ 20 years. The subjects were divided into four subgroups, namely CRP <median and LDL-C (TG) <median subgroup, CRP <median and LDL-C (TG) >median subgroup, CRP >median and LDL-C (TG)
The multivariate adjusted ORs (95%CIs) of hypertension/prehypertension were 1.389 (0.979-1.970)/1.151(0.865-1.531), 1.666 (1.159-2.394)/1.431 (1.060-1.930), 1.756 (1.242-2.484)/ 1.770 (1.321-2.372), for CRP
Subjects with both CRP >median and LDL-C (TG) >median had highest risks of hypertension and prehypertension among all subjects. This study appeared to indicate that the combined action of elevated CRP and elevated LDL-C (TG) further increase the risks of hypertension and prehypertension among Mongolian population.
许多研究表明，C反应蛋白（CRP）和血脂与高血压及心血管疾病（CVD）相关。然而，很少有研究探讨CRP和血脂对高血压及高血压前期风险的联合作用。本研究旨在调查CRP和血脂谱对中国内蒙古蒙古族成年人高血压及高血压前期风险的联合作用。
测量了2534名年龄≥20岁的蒙古族成年人的收缩压和舒张压、身高、体重及腰围，并调查了吸烟、饮酒、高血压家族史等因素，检测了CRP、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）。将受试者分为四个亚组，即CRP<中位数且LDL-C（TG）<中位数亚组、CRP<中位数且LDL-C（TG）>中位数亚组、CRP>中位数且LDL-C（TG）<中位数亚组以及CRP>中位数且LDL-C（TG）>中位数亚组。通过单因素和多因素分析计算各亚组高血压和高血压前期的OR值（95%可信区间）。
与CRP<中位数且LDL-C<中位数亚组相比，CRP<中位数且LDL-C>中位数亚组、CRP>中位数且LDL-C<中位数亚组、CRP>中位数且LDL-C>中位数亚组高血压/高血压前期的多因素调整OR值（95%可信区间）分别为1.389（0.979 - 1.970）/1.151（0.865 - 1.531）、1.666（1.159 - 2.394）/1.431（1.060 - 1.930）、1.756（1.242 - 2.484）/1.770（1.321 - 2.372）。同样，与CRP<中位数且TG<中位数亚组相比，CRP<中位数且TG>中位数亚组、CRP>中位数且TG<中位数亚组、CRP>中位数且TG>中位数亚组高血压/高血压前期的多因素调整OR值（95%可信区间）分别为2.032（1.394 - 2.963）/1.442（1.047 - 1.988）、1.412（0.960 - 2.079）/1.596（1.166 - 2.184）、2.197（1.595 - 3.027）/1.730（1.321 - 2.266）。在四个亚组中，CRP>中位数且LDL-C（TG）>中位数亚组的高血压和高血压前期风险最高。
在所有受试者中，CRP>中位数且LDL-C（TG）>中位数的受试者患高血压和高血压前期的风险最高。本研究似乎表明，CRP升高和LDL-C（TG）升高的联合作用会进一步增加蒙古族人群患高血压和高血压前期的风险。
