头颈癌治疗前体重指数的预后意义。
Prognostic significance of body mass index before treatment for head and neck cancer.
作者信息
Takenaka Yukinori, Takemoto Norihiko, Nakahara Susumu, Yamamoto Yoshifumi, Yasui Toshimichi, Hanamoto Atshushi, Fukusumi Takahito, Michiba Takahiro, Cho Hironori, Yamamoto Masashi, Inohara Hidenori
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
出版信息
Head Neck. 2015 Oct;37(10):1518-23. doi: 10.1002/hed.23785. Epub 2014 Jul 21.
BACKGROUND
Patients with head and neck cancer frequently experience malnutrition. The purpose of this study was to examine the impact of nutritional status on prognosis and its association with treatment modalities.
METHODS
This retrospective study included 706 patients with head and neck cancer diagnosed between 2004 and 2012. The effects of pretreatment body mass index (BMI) on overall survival were analyzed using the Kaplan-Meier method and Cox regression model.
RESULTS
BMI ranged from 11.6 to 38.0 kg/m2 (median, 21.5) and was a prognostic factor for survival, independent of primary site, and tumor stage. The 5-year survival rates for underweight, normal, and overweight groups were 32.2%, 62.7%, and 73.5%, respectively. The hazard ratios of BMI in the surgery, chemoradiation, and radiation groups were 0.95, 0.91, and 0.79, respectively, and the latter two were statistically significant.
CONCLUSION
The impact of BMI is determined by the types of cancer treatment. Pretreatment BMI should be considered while deciding treatment.
背景
头颈癌患者常出现营养不良。本研究旨在探讨营养状况对预后的影响及其与治疗方式的关联。
方法
这项回顾性研究纳入了2004年至2012年间诊断的706例头颈癌患者。采用Kaplan-Meier法和Cox回归模型分析治疗前体重指数（BMI）对总生存的影响。
结果
BMI范围为11.6至38.0kg/m²（中位数为21.5），是生存的预后因素，独立于原发部位和肿瘤分期。体重过轻、正常和超重组的5年生存率分别为32.2%、62.7%和73.5%。手术、放化疗和放疗组中BMI的风险比分别为0.95、0.91和0.79，后两者具有统计学意义。
结论
BMI的影响取决于癌症治疗的类型。决定治疗方案时应考虑治疗前BMI。
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