从刺激诱发电位估计神经锁相
Estimation of neural phase locking from stimulus-evoked potentials.
作者信息
Verschooten Eric, Joris Philip X
机构信息
Laboratory of Auditory Neurophysiology, KU Leuven, Herestraat 49 bus 1021, 3000, Leuven, Belgium,
出版信息
J Assoc Res Otolaryngol. 2014 Oct;15(5):767-87. doi: 10.1007/s10162-014-0465-9. Epub 2014 Jun 3.
Abstract
The frequency extent over which fine structure is coded in the auditory nerve has been physiologically characterized in laboratory animals but is unknown in humans. Knowledge of the upper frequency limit in humans would inform the debate regarding the role of fine structure in human hearing. Of the presently available techniques, only the recording of mass neural potentials offers the promise to provide a physiological estimate of neural phase locking in humans. A challenge is to disambiguate neural phase locking from the receptor potentials. We studied mass potentials recorded on the cochlea and auditory nerve of cat and used several experimental manipulations to isolate the neural contribution to these potentials. We find a surprisingly large neural contribution in the signal recorded on the cochlear round window, and this contribution is in many aspects similar to the potential measured on the auditory nerve. The results suggest that recording of mass potentials through the middle ear is a promising approach to examine neural phase locking in humans.
摘要
在实验动物中，听觉神经编码精细结构的频率范围已在生理学上得到了表征，但在人类中尚不清楚。了解人类的高频上限将为有关精细结构在人类听力中作用的争论提供依据。在目前可用的技术中，只有记录群体神经电位有望提供人类神经锁相的生理学估计。一个挑战是将神经锁相与感受器电位区分开来。我们研究了在猫的耳蜗和听觉神经上记录的群体电位，并使用了几种实验操作来分离神经对这些电位的贡献。我们发现在耳蜗圆窗记录的信号中，神经贡献惊人地大，而且这种贡献在许多方面与在听觉神经上测量的电位相似。结果表明，通过中耳记录群体电位是一种研究人类神经锁相的有前景的方法。
相似文献
1
Estimation of neural phase locking from stimulus-evoked potentials.从刺激诱发电位估计神经锁相
J Assoc Res Otolaryngol. 2014 Oct;15(5):767-87. doi: 10.1007/s10162-014-0465-9. Epub 2014 Jun 3.
2
Assessment of the limits of neural phase-locking using mass potentials.利用群体电位评估神经锁相的限度。
J Neurosci. 2015 Feb 4;35(5):2255-68. doi: 10.1523/JNEUROSCI.2979-14.2015.
3
Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope.听觉神经纤维的锁相揭示了刻板的失真和具有水平相关斜率的指数传递函数。
J Neurosci. 2019 May 22;39(21):4077-4099. doi: 10.1523/JNEUROSCI.1801-18.2019. Epub 2019 Mar 13.
4
Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.听觉神经纤维的锁相：毛细胞的低通滤波作用。
J Neurosci. 2020 Jun 10;40(24):4700-4714. doi: 10.1523/JNEUROSCI.2269-19.2020. Epub 2020 May 6.
5
Hair cell and neural contributions to the cochlear summating potential.毛细胞和神经对耳蜗总和电位的贡献。
J Neurophysiol. 2019 Jun 1;121(6):2163-2180. doi: 10.1152/jn.00006.2019. Epub 2019 Apr 3.
6
Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells.豚鼠耳蜗神经中的锁相及其与内毛细胞感受器电位的关系。
Hear Res. 1986;24(1):1-15. doi: 10.1016/0378-5955(86)90002-x.
7
On the origin of the compound action potentials (N1, N2) of the cochlea of the rat.
Exp Neurol. 1983 Jun;80(3):633-44. doi: 10.1016/0014-4886(83)90313-8.
8
Electrical cochlear stimulation in the deaf cat: comparisons between psychophysical and central auditory neuronal thresholds.聋猫的电耳蜗刺激：心理物理学阈值与中枢听觉神经元阈值的比较
J Neurophysiol. 2000 Apr;83(4):2145-62. doi: 10.1152/jn.2000.83.4.2145.
9
Quantifying envelope and fine-structure coding in auditory nerve responses to chimaeric speech.量化听觉神经对嵌合语音反应中的包络和精细结构编码。
J Assoc Res Otolaryngol. 2009 Sep;10(3):407-23. doi: 10.1007/s10162-009-0169-8. Epub 2009 Apr 14.
10
[An approach for proper recording of the unit discharge in auditory nerve and inferior colliculus].[一种用于正确记录听神经和下丘单位放电的方法]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct;23(5):481-4.
引用本文的文献
1
Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells.红外光通过毛细胞检测并放大的机械位移刺激耳蜗。
Proc Natl Acad Sci U S A. 2025 Apr 29;122(17):e2422076122. doi: 10.1073/pnas.2422076122. Epub 2025 Apr 24.
2
Evidence for the Auditory Nerve Generating Envelope Following Responses When Measured from Eardrum Electrodes.从鼓膜电极测量时听觉神经产生包络跟随反应的证据。
J Assoc Res Otolaryngol. 2025 Apr;26(2):147-162. doi: 10.1007/s10162-025-00979-0. Epub 2025 Mar 6.
3
Individualized Assays of Temporal Coding in the Ascending Human Auditory System.个体化的人类听觉上行系统时间编码分析。
eNeuro. 2022 Mar 11;9(2). doi: 10.1523/ENEURO.0378-21.2022. Print 2022 Mar-Apr.
4
Spectrally specific temporal analyses of spike-train responses to complex sounds: A unifying framework.对复杂声音的尖峰序列反应进行频谱特异性时间分析：一个统一框架。
PLoS Comput Biol. 2021 Feb 22;17(2):e1008155. doi: 10.1371/journal.pcbi.1008155. eCollection 2021 Feb.
5
The upper frequency limit for the use of phase locking to code temporal fine structure in humans: A compilation of viewpoints.人类中使用锁相编码时间精细结构的频率上限：观点汇编。
Hear Res. 2019 Jun;377:109-121. doi: 10.1016/j.heares.2019.03.011. Epub 2019 Mar 15.
6
High-resolution frequency tuning but not temporal coding in the human cochlea.人耳蜗的高分辨率频率调谐而非时间编码。
PLoS Biol. 2018 Oct 15;16(10):e2005164. doi: 10.1371/journal.pbio.2005164. eCollection 2018 Oct.
7
Residual Cochlear Function in Adults and Children Receiving Cochlear Implants: Correlations With Speech Perception Outcomes.成人和儿童植入人工耳蜗后的残余耳蜗功能：与言语感知结果的相关性。
Ear Hear. 2019 May/Jun;40(3):577-591. doi: 10.1097/AUD.0000000000000630.
8
Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms.圆窗耳蜗微音电位中的频谱波动：多种产生机制的证据
J Assoc Res Otolaryngol. 2018 Aug;19(4):401-419. doi: 10.1007/s10162-018-0668-6. Epub 2018 Jul 16.
9
A Model-Based Approach for Separating the Cochlear Microphonic from the Auditory Nerve Neurophonic in the Ongoing Response Using Electrocochleography.一种基于模型的方法，用于在使用电耳蜗图的持续反应中从听神经神经音中分离出耳蜗微音。
Front Neurosci. 2017 Oct 23;11:592. doi: 10.3389/fnins.2017.00592. eCollection 2017.
10
The Auditory Nerve Overlapped Waveform (ANOW) Detects Small Endolymphatic Manipulations That May Go Undetected by Conventional Measurements.听神经重叠波形（ANOW）可检测到一些常规测量可能无法发现的微小内淋巴操作。
Front Neurosci. 2017 Jul 18;11:405. doi: 10.3389/fnins.2017.00405. eCollection 2017.
本文引用的文献
1
Distinguishing hair cell from neural potentials recorded at the round window.从圆窗记录中区分毛细胞和神经电位。
J Neurophysiol. 2014 Feb;111(3):580-93. doi: 10.1152/jn.00446.2013. Epub 2013 Oct 16.
2
Auditory nerve frequency tuning measured with forward-masked compound action potentials.利用前掩蔽复合动作电位测量听神经频率调谐。
J Assoc Res Otolaryngol. 2012 Dec;13(6):799-817. doi: 10.1007/s10162-012-0346-z. Epub 2012 Sep 5.
3
A new auditory threshold estimation technique for low frequencies: proof of concept.一种新的低频听觉阈估计技术：概念验证。
Ear Hear. 2013 Jan-Feb;34(1):42-51. doi: 10.1097/AUD.0b013e31825f9bd3.
4
The group delay and suppression pattern of the cochlear microphonic potential recorded at the round window.记录在圆窗处的耳蜗微音电位的群延迟和抑制模式。
PLoS One. 2012;7(3):e34356. doi: 10.1371/journal.pone.0034356. Epub 2012 Mar 28.
5
The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people.时间精细结构处理在正常听力和听力受损人群的音高感知、掩蔽及言语感知中的作用。
J Assoc Res Otolaryngol. 2008 Dec;9(4):399-406. doi: 10.1007/s10162-008-0143-x. Epub 2008 Oct 15.
6
Nerve impulses in individual auditory nerve fibers of guinea pig.豚鼠单个听神经纤维中的神经冲动。
J Neurophysiol. 1954 Mar;17(2):97-122. doi: 10.1152/jn.1954.17.2.97.
7
Adaptation in hair cells.毛细胞的适应性。
Annu Rev Neurosci. 2000;23:285-314. doi: 10.1146/annurev.neuro.23.1.285.
8
Auditory nerve neurophonic recorded from the round window of the Mongolian gerbil.
Hear Res. 1995 Oct;90(1-2):176-84. doi: 10.1016/0378-5955(95)00162-6.
9
Enhancement of neural synchronization in the anteroventral cochlear nucleus. I. Responses to tones at the characteristic frequency.增强耳蜗腹侧前核中的神经同步。I. 对特征频率音调的反应。
J Neurophysiol. 1994 Mar;71(3):1022-36. doi: 10.1152/jn.1994.71.3.1022.
10
The relationship between spike rate and synchrony in responses of auditory-nerve fibers to single tones.听觉神经纤维对单音反应中放电率与同步性之间的关系。
J Acoust Soc Am. 1980 Oct;68(4):1115-22. doi: 10.1121/1.384982.
Zotero 插件