Verschooten Eric, Robles Luis, Joris Philip X
Laboratory of Auditory Neurophysiology, KU Leuven, B-3000 Leuven, Belgium, and.
Laboratory of Auditory Neurophysiology, KU Leuven, B-3000 Leuven, Belgium, and Program of Physiology and Biophysics, Universidad de Chile, Santiago, Chile, Independencia 1027, Santiago.
J Neurosci. 2015 Feb 4;35(5):2255-68. doi: 10.1523/JNEUROSCI.2979-14.2015.
In the diverse mechanosensory systems that animals evolved, the waveform of stimuli can be encoded by phase locking in spike trains of primary afferents. Coding of the fine structure of sounds via phase locking is thought to be critical for hearing. The upper frequency limit of phase locking varies across species and is unknown in humans. We applied a method developed previously, which is based on neural adaptation evoked by forward masking, to analyze mass potentials recorded on the cochlea and auditory nerve in the cat. The method allows us to separate neural phase locking from receptor potentials. We find that the frequency limit of neural phase locking obtained from mass potentials was very similar to that reported for individual auditory nerve fibers. The results suggest that this is a promising approach to examine neural phase locking in humans with normal or impaired hearing or in other species for which direct recordings from primary afferents are not feasible.
在动物进化出的多种机械感觉系统中，刺激波形可通过初级传入神经元的动作电位序列中的锁相进行编码。通过锁相对声音精细结构进行编码被认为对听觉至关重要。锁相的频率上限因物种而异，在人类中尚不清楚。我们应用了一种先前开发的方法，该方法基于前掩蔽诱发的神经适应，来分析猫耳蜗和听神经上记录的群体电位。该方法使我们能够将神经锁相与感受器电位分离。我们发现，从群体电位获得的神经锁相频率上限与单个听神经纤维的报道非常相似。结果表明，这是一种很有前景的方法，可用于检测听力正常或受损的人类或其他无法直接记录初级传入神经元的物种的神经锁相。
