Gioacchini Federico Maria, Alicandri-Ciufelli Matteo, Magliulo Giuseppe, Rubini Corrado, Presutti Livio, Re Massimo
Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy,
Eur Arch Otorhinolaryngol. 2015 Jul;272(7):1569-76. doi: 10.1007/s00405-014-3117-0. Epub 2014 Jun 3.
The aim of this study was to determine the prognostic value of Ki-67 immunostaining in patients affected by laryngeal squamous cell carcinoma. A systematic review was carried out in a tertiary university referral center. An appropriate string was run on PubMed to retrieve articles dealing with Ki-67 immunohistochemical staining and laryngeal squamous cell carcinoma. A double cross-check was performed on citations and full-text articles by two investigators independently to review all manuscripts and perform a comprehensive quality assessment. Of 85 abstracts identified, 18 articles were included. These studies reported on 1,342 patients with histological confirmed diagnosis of laryngeal squamous cell carcinoma. Most studies showed a statistical association between Ki-67 immunohistochemical expression and at least one of the clinical and histopathological parameters considered by the authors. Overall the studies analyzed suggested that the tumoral proliferative index was statistically connected respectively with T stage (2/18), N stage (4/18), grading (6/18), disease-free survival (10/18) and overall survival (4/18). Our review strongly suggests that immunohistochemical staining of Ki-67 correlates with tumoral aggressiveness and worse prognosis in patients affected by laryngeal squamous cell carcinoma. Further high-quality prospective studies should be carried out to confirm our finding and determine the eventual differences between cancers of specific laryngeal subsites.
本研究的目的是确定Ki-67免疫染色在喉鳞状细胞癌患者中的预后价值。在一所三级大学转诊中心进行了一项系统评价。在PubMed上运行了适当的检索词，以检索有关Ki-67免疫组化染色和喉鳞状细胞癌的文章。由两名研究人员独立对参考文献和全文文章进行双重交叉核对，以审查所有手稿并进行全面的质量评估。在识别出的85篇摘要中，纳入了18篇文章。这些研究报告了1342例经组织学确诊为喉鳞状细胞癌的患者。大多数研究表明，Ki-67免疫组化表达与作者所考虑的至少一项临床和组织病理学参数之间存在统计学关联。总体而言，所分析的研究表明，肿瘤增殖指数分别与T分期（2/18）、N分期（4/18）、分级（6/18）、无病生存期（10/18）和总生存期（4/18）存在统计学关联。我们的综述强烈表明，Ki-67免疫组化染色与喉鳞状细胞癌患者的肿瘤侵袭性和较差预后相关。应开展进一步的高质量前瞻性研究，以证实我们的发现，并确定特定喉亚部位癌症之间的最终差异。
