Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
Endocrinol Metab Clin North Am. 2014 Jun;43(2):529-43. doi: 10.1016/j.ecl.2014.02.006.
Overt hypothyroidism and thyrotoxicosis are associated with significant decrements in mood and cognitive function, and therapy usually leads to improvement in these symptoms. In contrast, major affective or cognitive dysfunction is not typical of subclinical thyroid disease. Subtle deficits in specific cognitive domains (primarily working memory and executive function) likely exist in subclinical hypothyroidism and thyrotoxicosis, but these are unlikely to cause major problems in most patients. Patients with mild thyroid disease and significant distress related to mood or cognition most likely have independent diagnoses that should be evaluated and treated separately.
显性甲状腺功能减退症和甲状腺功能亢进症与情绪和认知功能的显著下降有关，而治疗通常会导致这些症状的改善。相比之下，亚临床甲状腺疾病并非典型的主要情感或认知功能障碍。亚临床甲状腺功能减退症和甲状腺功能亢进症可能存在特定认知领域（主要是工作记忆和执行功能）的细微缺陷，但在大多数患者中不太可能导致重大问题。轻度甲状腺疾病且与情绪或认知相关的明显困扰的患者很可能有独立的诊断，这些诊断应该单独评估和治疗。
