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甲状腺疾病中的认知功能障碍研究。

Study of Cognitive Disfunctions in Thyroid Pathology.

作者信息

Nicola Marioara Oana-Maria, Popescu Mihaela, Vlădoianu Cristina-Nicoleta, Carlig Valentin, Carsote Mara, Ghenea Alice Elena

机构信息

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova.

出版信息

Curr Health Sci J. 2021 Apr-Jun;47(2):256-262. doi: 10.12865/CHSJ.47.02.16. Epub 2021 Jun 30.

DOI:10.12865/CHSJ.47.02.16
PMID:34765246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8551900/
Abstract

Thyroid pathology is characterized by abnormal values of thyroid hormones that can affect the brain and can lead to cognitive impairment (attention, memory, mood), depression and anxiety. The aim of the study is to evaluate the association between the cognitive disorders and thyroid disease and the link between thyroid hormone levels FT4 and TSH in depression and anxiety. We included 130 individuals from Endocrinology Clinic of Craiova, over a period of 6 years (2014-2020), none of whom was taking thyroid medication and antidepressants. The most important symptom found in thyroid pathology is depression, which occurs in those with long-lasting illness. We obtained that 45.38% of the cases were diagnosed with depression and 46.92% with anxiety. Depressive symptoms were assessed with Hamilton scale and anxiety symptoms with the Beck scale. Regarding the impaired cognitive function, we found it in 34.7% of cases of hypothyroidism (loss of memory / lack of concentration) and for the cases with hyperthyroidism, we found changes in 51,42%.

摘要

甲状腺病理的特征是甲状腺激素值异常，这会影响大脑并可能导致认知障碍（注意力、记忆力、情绪）、抑郁和焦虑。本研究的目的是评估认知障碍与甲状腺疾病之间的关联，以及抑郁症和焦虑症中甲状腺激素水平FT4和TSH之间的联系。我们纳入了来自克拉约瓦内分泌诊所的130名个体，为期6年（2014年至2020年），他们均未服用甲状腺药物和抗抑郁药。在甲状腺病理中发现的最重要症状是抑郁症，它发生在患有长期疾病的患者中。我们发现45.38%的病例被诊断为抑郁症，46.92%的病例被诊断为焦虑症。用汉密尔顿量表评估抑郁症状，用贝克量表评估焦虑症状。关于认知功能受损，我们在34.7%的甲状腺功能减退病例中发现了这种情况（记忆力丧失/注意力不集中），而在甲状腺功能亢进病例中，我们发现有51.42%的病例出现了变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/57aab231e9e1/CHSJ-47-02-256-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/d73c296d5a00/CHSJ-47-02-256-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/b6b833bb6e9b/CHSJ-47-02-256-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/ae13f0e7f1f1/CHSJ-47-02-256-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/df7eef658244/CHSJ-47-02-256-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/e159291ef228/CHSJ-47-02-256-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/96d93c01eb07/CHSJ-47-02-256-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/fc7a27c9c566/CHSJ-47-02-256-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/57aab231e9e1/CHSJ-47-02-256-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/d73c296d5a00/CHSJ-47-02-256-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/b81dbf3d156e/CHSJ-47-02-256-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/246234c1cf23/CHSJ-47-02-256-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/d487a4d54e83/CHSJ-47-02-256-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/b6b833bb6e9b/CHSJ-47-02-256-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/ae13f0e7f1f1/CHSJ-47-02-256-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/df7eef658244/CHSJ-47-02-256-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/e159291ef228/CHSJ-47-02-256-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/96d93c01eb07/CHSJ-47-02-256-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/fc7a27c9c566/CHSJ-47-02-256-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd6a/8551900/57aab231e9e1/CHSJ-47-02-256-fig11.jpg

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