铜催化的苄位 C-H 键的直接三氟甲硫基化反应：通过非定向氧化 C(sp3)-H 活化。
Copper-catalyzed direct trifluoromethylthiolation of benzylic C-H bonds via nondirected oxidative C(sp3)-H activation.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2014 Jun 20;16(12):3372-5. doi: 10.1021/ol501400u. Epub 2014 Jun 3.
PMID:24892973
Abstract
A copper-catalyzed trifluoromethylthiolation of benzylic sp(3) C-H bonds was developed via nondirected oxidative C-H activation using readily prepared and stable AgSCF3. This reaction provides a novel and straightforward method for the preparation of various benzyl trifluoromethyl sulfides.
摘要
发展了一种铜催化的苄位 sp(3) C-H 键三氟甲基化反应，通过使用易于制备和稳定的 AgSCF3 进行非定向氧化 C-H 活化。该反应为各种苄基三氟甲基硫化物的制备提供了一种新颖而直接的方法。
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