Inglese Matilde, Petracca Maria
Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA.
Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, USA; Department of Neuroscience, University "Federico II", Naples, Italy.
Schizophr Res. 2015 Jan;161(1):94-101. doi: 10.1016/j.schres.2014.04.040. Epub 2014 Jun 2.
Multiple sclerosis is the leading nontraumatic cause of neurologic disability in young adults. The need to prevent neurodegeneration and promote repair in multiple sclerosis (MS) has gained increasing interest in the last decade leading to the search and development of pharmacological agents and non-pharmacologic strategies able to target not only the inflammatory but also the neurodegenerative component of the disease. This paper will provide an overview of the therapeutics currently employed in MS, with a focus on their potential neuroprotective effects and on the MRI methods employed to detect and monitor in-vivo neuroprotection and repair and the relevance of this information to schizophrenia investigation and treatment.
多发性硬化症是年轻成年人非创伤性神经功能障碍的主要原因。在过去十年中，预防多发性硬化症（MS）中的神经退行性变和促进修复的需求越来越受到关注，这促使人们寻找和开发不仅能够针对该疾病的炎症成分，而且能够针对神经退行性成分的药物制剂和非药物策略。本文将概述目前在MS中使用的治疗方法，重点关注其潜在的神经保护作用，以及用于检测和监测体内神经保护和修复的MRI方法，以及这些信息与精神分裂症研究和治疗的相关性。
