NAD+ 控制衰老大脑中的神经干细胞命运。
NAD+ controls neural stem cell fate in the aging brain.
机构信息
Buck Institute for Research on Aging, Novato, CA, USA.
Buck Institute for Research on Aging, Novato, CA, USA Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
出版信息
EMBO J. 2014 Jun 17;33(12):1289-91. doi: 10.15252/embj.201488969. Epub 2014 Jun 3.
Abstract
Loss of the coenzyme NAD, which is required for many energy-dependent cellular processes, has emerged as a potentially unifying mechanism for age-related conditions. A study in this issue of identifies a novel link between depletion of NAD and age-associated loss of proliferating adult neural stem/progenitor cells in the murine brain (Stein & Imai, 2014). These data have important implications for how brain function might decline with age.
摘要
辅酶 NAD 的耗竭会影响许多依赖能量的细胞过程，它的耗竭被认为是与衰老相关疾病的一个潜在的统一机制。本期杂志中的一项研究（Stein & Imai, 2014）确定了 NAD 耗竭与衰老相关的成年神经干细胞/祖细胞在小鼠大脑中增殖能力丧失之间的新联系。这些数据对于了解大脑功能随年龄增长而下降的机制具有重要意义。
相似文献
1
NAD+ controls neural stem cell fate in the aging brain.NAD+ 控制衰老大脑中的神经干细胞命运。
EMBO J. 2014 Jun 17;33(12):1289-91. doi: 10.15252/embj.201488969. Epub 2014 Jun 3.
2
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.特异性消融成体神经干细胞中的 Nampt 可重现其衰老过程中的功能缺陷。
EMBO J. 2014 Jun 17;33(12):1321-40. doi: 10.1002/embj.201386917. Epub 2014 May 8.
3
Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals.烟酰胺磷酸核糖转移酶（Nampt）影响间充质干细胞的谱系命运决定：老年人骨生成减少和脂肪生成增加的一个可能原因。
J Bone Miner Res. 2011 Nov;26(11):2656-64. doi: 10.1002/jbmr.480.
4
Loss of NAMPT in aging retinal pigment epithelium reduces NAD availability and promotes cellular senescence.衰老视网膜色素上皮细胞中烟酰胺磷酸核糖转移酶（NAMPT）的缺失会降低烟酰胺腺嘌呤二核苷酸（NAD）的可用性并促进细胞衰老。
Aging (Albany NY). 2018 Jun 12;10(6):1306-1323. doi: 10.18632/aging.101469.
5
Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.靶向烟酰胺磷酸核糖转移酶作为一种潜在的治疗策略，以恢复成年神经发生。
CNS Neurosci Ther. 2016 Jun;22(6):431-9. doi: 10.1111/cns.12539. Epub 2016 Mar 28.
6
Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world.迈向富有成效的衰老：SIRT1、系统性 NAD 生物合成和 NAD 世界。
Cornea. 2010 Nov;29 Suppl 1:S7-12. doi: 10.1097/ICO.0b013e3181ea4714.
7
NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way.烟酰胺磷酸核糖转移酶介导的烟酰胺腺嘌呤二核苷酸生物合成作为内部计时机制：在烟酰胺腺嘌呤二核苷酸（NAD+）的世界里，时间以它自己的方式流逝。
Rejuvenation Res. 2018 Jun;21(3):210-224. doi: 10.1089/rej.2017.1975. Epub 2017 Sep 8.
8
Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.烟酰胺磷酸核糖转移酶（Nampt）可能作为骨髓间充质干细胞成骨分化的标志物。
Exp Cell Res. 2017 Mar 1;352(1):45-52. doi: 10.1016/j.yexcr.2017.01.021. Epub 2017 Jan 31.
9
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases.烟酰胺磷酸核糖基转移酶可能与年龄相关性脑疾病有关。
PLoS One. 2012;7(10):e44933. doi: 10.1371/journal.pone.0044933. Epub 2012 Oct 11.
10
Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging.成年神经干细胞及其龛：在稳态、再生和衰老过程中的动态偶联。
Curr Opin Neurobiol. 2013 Dec;23(6):935-42. doi: 10.1016/j.conb.2013.09.004. Epub 2013 Oct 1.
引用本文的文献
1
Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against HO-Induced Senescence.抗氧化剂可改善人脐带间充质干细胞对抗骨化性肌炎诱导的衰老的增殖能力及功效。
Antioxidants (Basel). 2023 Jun 24;12(7):1334. doi: 10.3390/antiox12071334.
2
NAD+ Modulates the Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells via Akt Signaling Pathway.NAD+ 通过 Akt 信号通路调节成年神经干细胞/祖细胞的增殖和分化。
Cells. 2022 Apr 9;11(8):1283. doi: 10.3390/cells11081283.
3
NAD and the aging process: Role in life, death and everything in between.NAD 与衰老过程：在生命、死亡及其间的一切中的作用。
Mol Cell Endocrinol. 2017 Nov 5;455:62-74. doi: 10.1016/j.mce.2016.11.003. Epub 2016 Nov 5.
4
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.体内NAD测定揭示了健康人脑内的细胞内NAD含量、氧化还原状态及其年龄依赖性。
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2876-81. doi: 10.1073/pnas.1417921112. Epub 2015 Feb 17.
5
Metabolic regulation of histone post-translational modifications.组蛋白翻译后修饰的代谢调控
ACS Chem Biol. 2015 Jan 16;10(1):95-108. doi: 10.1021/cb500846u.
本文引用的文献
1
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.特异性消融成体神经干细胞中的 Nampt 可重现其衰老过程中的功能缺陷。
EMBO J. 2014 Jun 17;33(12):1321-40. doi: 10.1002/embj.201386917. Epub 2014 May 8.
2
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.NAD(+) 的下降会导致一种假缺氧状态，在衰老过程中破坏核-线粒体通讯。
Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037.
3
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.烟酰胺单核苷酸，一种关键的 NAD(+)中间体，可治疗饮食和年龄引起的糖尿病的病理生理学在小鼠。
Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016/j.cmet.2011.08.014.
4
Emerging models and paradigms for stem cell ageing.新兴的干细胞衰老模型和范式。
Nat Cell Biol. 2011 May;13(5):506-12. doi: 10.1038/ncb0511-506.
5
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.中枢神经系统限制转录因子 Olig2 拮抗神经祖细胞和恶性神经胶质瘤中 p53 对遗传毒性损伤的反应。
Cancer Cell. 2011 Mar 8;19(3):359-71. doi: 10.1016/j.ccr.2011.01.035.
6
Phosphorylation state of Olig2 regulates proliferation of neural progenitors.Olig2 的磷酸化状态调节神经前体细胞的增殖。
Neuron. 2011 Mar 10;69(5):906-17. doi: 10.1016/j.neuron.2011.02.005.
7
Mammalian sirtuins: biological insights and disease relevance.哺乳动物的 sirtuins：生物学见解和疾病相关性。
Annu Rev Pathol. 2010;5:253-95. doi: 10.1146/annurev.pathol.4.110807.092250.
8
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.通过烟酰胺磷酸核糖转移酶（NAMPT）介导的烟酰胺腺嘌呤二核苷酸（NAD+）生物合成的昼夜节律时钟反馈循环。
Science. 2009 May 1;324(5927):651-4. doi: 10.1126/science.1171641. Epub 2009 Mar 19.
9
Nampt: linking NAD biology, metabolism and cancer.烟酰胺磷酸核糖转移酶（Nampt）：连接烟酰胺腺嘌呤二核苷酸（NAD）生物学、代谢与癌症
Trends Endocrinol Metab. 2009 Apr;20(3):130-8. doi: 10.1016/j.tem.2008.10.004. Epub 2008 Dec 26.
10
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.葡萄糖限制通过AMPK介导的Nampt调节激活SIRT1，从而抑制骨骼肌成肌细胞分化。
Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.
Zotero 插件