Buck Institute for Research on Aging, Novato, CA, USA.
Buck Institute for Research on Aging, Novato, CA, USA Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
EMBO J. 2014 Jun 17;33(12):1289-91. doi: 10.15252/embj.201488969. Epub 2014 Jun 3.
Loss of the coenzyme NAD, which is required for many energy-dependent cellular processes, has emerged as a potentially unifying mechanism for age-related conditions. A study in this issue of identifies a novel link between depletion of NAD and age-associated loss of proliferating adult neural stem/progenitor cells in the murine brain (Stein & Imai, 2014). These data have important implications for how brain function might decline with age.
辅酶 NAD 的耗竭会影响许多依赖能量的细胞过程，它的耗竭被认为是与衰老相关疾病的一个潜在的统一机制。本期杂志中的一项研究（Stein & Imai, 2014）确定了 NAD 耗竭与衰老相关的成年神经干细胞/祖细胞在小鼠大脑中增殖能力丧失之间的新联系。这些数据对于了解大脑功能随年龄增长而下降的机制具有重要意义。
