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柠檬桉叶中的化学成分及其对葡萄糖转运蛋白 4 的转位活性。

Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities.

机构信息

College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.

College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.

出版信息

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3096-9. doi: 10.1016/j.bmcl.2014.05.014. Epub 2014 May 16.

DOI:10.1016/j.bmcl.2014.05.014
PMID:24894556
Abstract

Bioassay-guided phytochemical investigation of the EtOAc fraction from the leaves of a Chinese medicinal herb, Eucalyptus citriodora Hook, resulted in the isolation of a new compound rhodomyrtosone E (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and X-ray crystallographic analysis. Betulinic acid (2) and corosolic acid (5) increased glucose transporter 4 (GLUT-4) translocation by 2.38 and 1.78-fold, respectively.

摘要

生物测定指导的中药柠檬桉叶乙酸乙酯部位的化学成分研究，分离得到一个新化合物 rhodomyrtosone E（1），同时还分离得到 12 个已知化合物（2-13）。新化合物的结构通过 1D 和 2D NMR、MS 数据和 X 射线晶体学分析确定。白桦脂酸（2）和齐墩果酸（5）分别使葡萄糖转运蛋白 4（GLUT-4）的易位增加了 2.38 倍和 1.78 倍。

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