Yang Xinzhou, Deng Shihao, Huang Mi, Wang Jialin, Chen Li, Xiong Mingrui, Yang Jie, Zheng Sijiang, Ma Xinhua, Zhao Ping, Feng Yunjiang
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1463-1466. doi: 10.1016/j.bmcl.2017.01.078. Epub 2017 Jan 30.
Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
对越南槐根乙酸乙酯部位（ST-EtOAc）进行生物活性导向的植物化学研究，从中分离得到一个新化合物6aR,11aR-1-羟基-4-异戊烯基苦参啶（1），以及12个已知化合物（2 - 13）。通过一维和二维核磁共振、质谱数据以及圆二色性分析确定了该新化合物的结构。多异戊烯基黄酮6 - 9和11 - 13使葡萄糖转运蛋白4（GLUT-4）易位增加了1.35 - 2.75倍。槐果酮（8）活性最强，在浓度为10μM时使GLUT-4易位增强2.75倍。这是关于越南槐植物GLUT-4易位活性的首次报道。
