越南槐的化学成分及其葡萄糖转运蛋白4转位活性
Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities.
作者信息
Yang Xinzhou, Deng Shihao, Huang Mi, Wang Jialin, Chen Li, Xiong Mingrui, Yang Jie, Zheng Sijiang, Ma Xinhua, Zhao Ping, Feng Yunjiang
机构信息
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
出版信息
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1463-1466. doi: 10.1016/j.bmcl.2017.01.078. Epub 2017 Jan 30.
Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
对越南槐根乙酸乙酯部位（ST-EtOAc）进行生物活性导向的植物化学研究，从中分离得到一个新化合物6aR,11aR-1-羟基-4-异戊烯基苦参啶（1），以及12个已知化合物（2 - 13）。通过一维和二维核磁共振、质谱数据以及圆二色性分析确定了该新化合物的结构。多异戊烯基黄酮6 - 9和11 - 13使葡萄糖转运蛋白4（GLUT-4）易位增加了1.35 - 2.75倍。槐果酮（8）活性最强，在浓度为10μM时使GLUT-4易位增强2.75倍。这是关于越南槐植物GLUT-4易位活性的首次报道。
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