Chhablani Jay, Kozak Igor, Jonnadula Ganesh Babu, Venkata Amarnath, Narayanan Raja, Pappuru Rajeev Reddy, Rao Podili Srinivas
*Smt.Kanuri Santhamma Retina Vitreous Centre, L. V. Prasad Eye Institute, Hyderabad, India; †Division of Vitreoretinal Diseases and Surgery, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; and ‡L. V. Prasad Eye Institute, Kode Venkatadri Chowdary Campus, Vijayawada, India.
Retina. 2014 Sep;34(9):1819-23. doi: 10.1097/IAE.0000000000000180.
To assess the choroidal thickness changes in eyes with macular telangiectasia Type 2 and their relationship with the integrity of outer retinal structures and visual acuity.
This is a prospective observational study that included 81 eyes (41 subjects) with macular telangiectasia Type 2, including 21 women who underwent enhanced depth choroidal imaging. The choroidal thickness measurements were made at the fovea and at 5 points with an interval of 500 μm in both directions, nasal and temporal from the fovea, and were compared with age-matched healthy subjects. Masked observers assessed the outer retinal structure integrity. Stepwise regression was used to find the relationship between age, spherical equivalent, central macular thickness, integrity of the inner segment/outer segment junction, external limiting membrane integrity, and subfoveal choroidal thickness (SFCT).
The mean age of the subjects was 55.2 ± 7.8 years in study subjects. The mean SFCT was 274.6 ± 45.7 μm. There was no significant difference between the SFCT in eyes with macular telangiectasia Type 2 and age-matched healthy subjects (P = 0.38). There was no correlation between the visual acuity (r = 0.008); integrity of inner segment/outer segment (r = 0.54); external limiting membrane (r = 0.47); central macular thickness (r = 0.31) and SFCT.
Choroidal thickness did not vary between eyes with macular telangiectasia Type 2 and age-matched healthy subjects. There was no correlation between SFCT and visual acuity, and integrity of the outer retinal structures and central macular thickness.
评估2型黄斑毛细血管扩张症患者脉络膜厚度变化及其与视网膜外层结构完整性和视力的关系。
这是一项前瞻性观察性研究，纳入81只患2型黄斑毛细血管扩张症的眼睛（41名受试者），其中21名女性接受了增强深度脉络膜成像。在黄斑中心凹以及从中心凹向鼻侧和颞侧两个方向每隔500μm的5个点测量脉络膜厚度，并与年龄匹配的健康受试者进行比较。由盲法观察者评估视网膜外层结构的完整性。采用逐步回归分析来确定年龄、等效球镜度、中心黄斑厚度、内节/外节连接的完整性、外界膜完整性和黄斑中心凹下脉络膜厚度（SFCT）之间的关系。
研究对象的平均年龄为55.2±7.8岁。平均SFCT为274.6±45.7μm。2型黄斑毛细血管扩张症患者的SFCT与年龄匹配的健康受试者之间无显著差异（P = 0.38）。视力（r = 0.008）、内节/外节完整性（r = 0.54）、外界膜（r = 0.47）、中心黄斑厚度（r = 0.31）与SFCT之间均无相关性。
2型黄斑毛细血管扩张症患者与年龄匹配的健康受试者之间脉络膜厚度无差异。SFCT与视力、视网膜外层结构完整性及中心黄斑厚度之间无相关性。
