聚（ADP-核糖）聚合酶在细胞死亡中的作用。

Involvement of PARPs in cell death.

作者信息

Aredia Francesca, Scovassi Anna Ivana

机构信息

Istituto di Genetica Molecolare CNR, Pavia, Italy.

出版信息

Front Biosci (Elite Ed). 2014 Jun 1;6(2):308-17. doi: 10.2741/707.

DOI:10.2741/707

PMID:24896207

Abstract

Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e.apoptosis, parthanatos, necroptosis and autophagy.

摘要

聚（ADP-核糖基化）是一种依赖NAD的反应，最终形成ADP-核糖单体，并随后进行聚合，在DNA损伤和细胞应激等关键情况下作为一种应急过程被激活；由于这一关键功能，人们已经研究了细胞死亡过程中聚（ADP-核糖基化）的调节。本综述将描述聚（ADP-核糖）作为信号分子在不同细胞死亡模式（即凋亡、PARP-1依赖性坏死、坏死性凋亡和自噬）中的特性。