Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
Biochem Pharmacol. 2014 Nov 1;92(1):157-63. doi: 10.1016/j.bcp.2014.06.021. Epub 2014 Jun 26.
Poly(ADP-ribosylation) results from the conversion of NAD(+) into ADP-ribose and the following addition of ADP-ribose units to form polymers, further bound to acceptor proteins; once post-translationally ADP-ribosylated, proteins could change their function in basic processes. Poly(ADP-ribosylation) is activated under critical situations represented by DNA damage and cellular stress, and modulated in different paradigms of cell death. The hallmarks of the main death processes, i.e. apoptosis, parthanatos, necroptosis and autophagy, will be described, focusing on the role of poly(ADP-ribose) as a signaling molecule.
聚（ADP-核糖）化是 NAD（+）转化为 ADP-核糖，随后 ADP-核糖单位添加形成聚合物，并进一步与受体蛋白结合的结果；一旦发生翻译后 ADP-核糖基化，蛋白质的功能可能会在基础过程中发生改变。聚（ADP-核糖）化在以 DNA 损伤和细胞应激为代表的危急情况下被激活，并在不同的细胞死亡模式中被调节。主要死亡过程（即细胞凋亡、parthanatos、坏死性凋亡和自噬）的特征将被描述，重点是聚（ADP-核糖）作为信号分子的作用。
