Tseng Yen-Ju, Yang Yuan-Chien, Wang Shang-Kwei, Duh Chang-Yih
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Mar Drugs. 2014 Jun 3;12(6):3371-80. doi: 10.3390/md12063371.
Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM.
numerosol A-D（1-4）；以及一种已知的甾体化合物，gibberoketosterol（5）。通过对光谱数据的广泛分析确定了这些代谢产物的结构。gibberoketosterol（5）对P-388（小鼠淋巴细胞白血病）细胞系表现出细胞毒性，半数有效剂量（ED50）为6.9 μM。
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