厚棒盘海绵素M-R，从台湾软珊瑚紫厚棒盘海绵中分离得到的六种新型二萜类化合物。
Pachyclavulariolides M-R, six novel diterpenoids from a Taiwanese soft coral Pachyclavularia violacea.
作者信息
Sheu Jyh-Horng, Wang Guey-Horng, Duh Chang-Yih, Soong Keryea
机构信息
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
出版信息
J Nat Prod. 2003 May;66(5):662-6. doi: 10.1021/np020603j.
PMID:12762802
Abstract
Six novel diterpenoids, pachyclavulariolides M-R (1-6), have been isolated from a Taiwanese soft coral Pachyclavularia violacea. The structures and relative stereochemistry of compounds 1-6 were established by spectroscopic analyses. Compound 1 has been shown to exhibit significant cytotoxicity toward P-388 cancer cells. Biosynthesis of 4-6 is discussed.
摘要
从台湾软珊瑚紫厚丛柳珊瑚（Pachyclavularia violacea）中分离出了6种新型二萜类化合物，厚丛柳珊瑚内酯M - R（1 - 6）。通过光谱分析确定了化合物1 - 6的结构和相对立体化学。已证明化合物1对P - 388癌细胞具有显著的细胞毒性。并对化合物4 - 6的生物合成进行了讨论。
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