Mürtz P, Tsesarskiy M, Kowal A, Träber F, Gieseke J, Willinek W A, Leutner C C, Schmiedel A, Schild H H
Department of Radiology, University of Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Germany,
Eur Radiol. 2014 Oct;24(10):2540-51. doi: 10.1007/s00330-014-3235-5. Epub 2014 Jun 5.
The aim of this study was to evaluate the influence of different fat-suppression techniques on quantitative measurements and their reproducibility when applied to diffusion-weighted imaging (DWI) of breast lesions.
Twenty-five patients with different types of breast lesions were examined on a clinical 1.5-T magnetic resonance imaging (MRI) system. Two diffusion-weighted sequences with different fat-suppression methods were applied: one with spectral presaturation by inversion recovery (SPIR), and one with short-TI inversion recovery (STIR). The acquisition of both sequence variants was repeated with modified shim volume. Lesion-to-background contrast (LBC), apparent diffusion coefficients (ADC) ADC(0,1000) and ADC(50,1000), and their coefficients of variation (CV) were determined.
In four patients, the image quality of DWI with SPIR was insufficient. In the other 21 patients, 46 regions of interest (ROI), including 11 malignant and 35 benign lesions, were analysed. The LBC, ADC(0,1000) and ADC(50,1000) values, which did not differ between initial and repeated measurements, were significantly higher for STIR than for SPIR. The mean CV improved from 10.8 % to 4.0 % (P = 0.0047) for LBC, from 6.3 % to 2.9 % (P = 0.0041) for ADC(0,1000), and from 6.3 % to 2.6 % (P = 0.0049) for ADC(50,1000).
For STIR compared to SPIR fat suppression, improved lesion conspicuity, higher ADC values, and better measurement reproducibility were found in breast DWI.
• Quality of fat suppression influences quantitative DWI breast lesion measurements. • In breast DWI, STIR fat suppression worked more reliably than SPIR. • Lesion-to-background contrast and its reproducibility were significantly higher with STIR fat suppression. • Lesional ADCs and their reproducibility were significantly higher with STIR fat suppression.
本研究旨在评估不同脂肪抑制技术应用于乳腺病变扩散加权成像（DWI）时对定量测量及其可重复性的影响。
在临床1.5-T磁共振成像（MRI）系统上对25例患有不同类型乳腺病变的患者进行检查。应用两种采用不同脂肪抑制方法的扩散加权序列：一种采用反转恢复频谱预饱和（SPIR），另一种采用短TI反转恢复（STIR）。两种序列变体的采集均采用改良匀场容积重复进行。测定病变与背景对比度（LBC）、表观扩散系数（ADC）的ADC(0,1000)和ADC(50,1000)及其变异系数（CV）。
4例患者采用SPIR的DWI图像质量不足。在其他21例患者中，分析了46个感兴趣区域（ROI），包括11个恶性病变和35个良性病变。LBC、ADC(0,1000)和ADC(50,1000)值在初次测量和重复测量之间无差异，STIR序列的这些值显著高于SPIR序列。LBC的平均CV从10.8%提高到4.0%（P = 0.0047），ADC(0,1000)的平均CV从6.3%提高到2.9%（P = 0.0041），ADC(50,1000)的平均CV从6.3%提高到2.6%（P = 0.0049）。
与SPIR脂肪抑制相比，STIR脂肪抑制在乳腺DWI中可提高病变的清晰度、获得更高的ADC值以及更好的测量可重复性。
• 脂肪抑制质量影响乳腺病变定量DWI测量。• 在乳腺DWI中，STIR脂肪抑制比SPIR更可靠。• STIR脂肪抑制下病变与背景对比度及其可重复性显著更高。• STIR脂肪抑制下病变ADC值及其可重复性显著更高。
