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微小RNA作为心血管疾病的治疗靶点和生物标志物

MicroRNAs as therapeutic targets and biomarkers of cardiovascular disease.

作者信息

Olson Eric N

机构信息

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

出版信息

Sci Transl Med. 2014 Jun 4;6(239):239ps3. doi: 10.1126/scitranslmed.3009008.

DOI:10.1126/scitranslmed.3009008
PMID:24898744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4279862/
Abstract

MicroRNAs play central roles in cardiovascular disease, and their therapeutic manipulation raises exciting opportunities as well as challenges in the path toward clinical development.

摘要

微小RNA在心血管疾病中发挥着核心作用,对其进行治疗性调控在迈向临床开发的道路上带来了令人兴奋的机遇和挑战。

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Inhibition of miR-25 improves cardiac contractility in the failing heart.抑制 miR-25 可改善心力衰竭心脏的收缩功能。
Nature. 2014 Apr 24;508(7497):531-5. doi: 10.1038/nature13073. Epub 2014 Mar 12.
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1.MicroRNA-126-5p 通过抑制 Dlk1 促进内皮细胞增殖并限制动脉粥样硬化。
Inferring single-cell and spatial microRNA activity from transcriptomics data.
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Commun Biol. 2025 Jan 18;8(1):87. doi: 10.1038/s42003-025-07454-9.
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Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.白藜芦醇通过微小RNA-33/沉默调节蛋白6信号通路抑制肝脏脂肪酸合成并增加脂肪酸β氧化。
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