用于猪流感分型和疫苗效力研究的体内模型
In vivo models for pathotyping and vaccine efficacy for swine influenza.
作者信息
Lager Kelly M, Vincent Amy L
机构信息
Virus and Prion Research Unit, National Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, 1920 Dayton Avenue, Ames, IA, 50010, USA,
出版信息
Methods Mol Biol. 2014;1161:355-61. doi: 10.1007/978-1-4939-0758-8_30.
Swine influenza is a disease of the respiratory tract caused by influenza A virus (IAV). Experimental inoculation of pigs involves either aerosolization and inhalation of virus or the direct introduction of virus into the upper or lower respiratory tract. This chapter covers methods for experimental IAV infection of pigs and collection of specific samples to study the pathogenesis of swine influenza and vaccine efficacy.
猪流感是一种由甲型流感病毒（IAV）引起的呼吸道疾病。猪的实验性接种涉及病毒的雾化和吸入，或直接将病毒引入上呼吸道或下呼吸道。本章涵盖了猪的实验性IAV感染方法以及用于研究猪流感发病机制和疫苗效力的特定样本的采集。
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