Dirani Ali, Matet Alexandre, Beydoun Talal, Mantel Irmela, Behar-Cohen Francine
Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland.
Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
Clin Ophthalmol. 2014 May 20;8:999-1002. doi: 10.2147/OPTH.S62267. eCollection 2014.
Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist.
穹窿状黄斑（DSM）最近在近视患者中被描述为黄斑在后部巩膜葡萄肿内的凸状突出。DSM的发病机制以及相关浆液性黄斑脱离（SFD）的发展仍不清楚。脉络膜流出受阻和脉络膜毛细血管的压缩性变化已被提出作为致病因素。在本文中，我们报告了两例口服螺内酯治疗的与DSM相关的慢性SFD患者。治疗后，两名患者的SFD均完全消退。据我们所知，这是首次报道用盐皮质激素受体拮抗剂成功治疗DSM中的SFD。
