生活方式与晚期糖基化终末产物（AGEs）负担：其与健康衰老的相关性。
Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging.
作者信息
Prasad Chandan, Imrhan Victorine, Marotta Francesco, Juma Shanil, Vijayagopal Parakat
机构信息
Department of Nutrition and Food Sciences, Texas Woman's University, Denton, Texas, USA.
ReGenera Research group for Aging Intervention, Milano, Italy.
出版信息
Aging Dis. 2014 Jun 1;5(3):212-7. doi: 10.14336/AD.2014.0500212. eCollection 2014 Jun.
Abstract
Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.
摘要
不受控制的持续氧化应激暴露是许多慢性疾病的先兆，包括癌症、糖尿病、退行性疾病和心血管疾病。在众多已知的氧化应激介质中，活性氧（ROS）和晚期糖基化终产物（AGEs）是研究最多的。在本综述中，我们总结了关于循环AGEs来源的当前数据，讨论了与其稳态水平可靠评估相关的问题，以及其水平随年龄和某些代谢疾病的变化。最后，我们对可能降低AGEs负担以促进健康衰老的生活方式改变提出了建议。
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本文引用的文献
1
Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?
Crit Rev Food Sci Nutr. 2016;56(6):989-98. doi: 10.1080/10408398.2012.744738.
2
Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression.
Osteoarthritis Cartilage. 2012 Jul;20(7):736-44. doi: 10.1016/j.joca.2012.03.012. Epub 2012 Mar 30.
3
Advanced glycation end products and diabetic cardiovascular disease.
Cardiol Rev. 2012 Jul-Aug;20(4):177-83. doi: 10.1097/CRD.0b013e318244e57c.
4
Dietary advanced glycation end products and aging.
Nutrients. 2010 Dec;2(12):1247-65. doi: 10.3390/nu2121247. Epub 2010 Dec 13.
5
RAGE: a single receptor fits multiple ligands.
Trends Biochem Sci. 2011 Dec;36(12):625-32. doi: 10.1016/j.tibs.2011.08.008. Epub 2011 Oct 19.
6
Alternative splicing of RAGE: roles in biology and disease.
Front Biosci (Landmark Ed). 2011 Jun 1;16(7):2756-70. doi: 10.2741/3884.
7
RAGE biology, atherosclerosis and diabetes.
Clin Sci (Lond). 2011 Jul;121(2):43-55. doi: 10.1042/CS20100501.
8
Advanced glycation endproducts: from precursors to RAGE: round and round we go.
Amino Acids. 2012 Apr;42(4):1151-61. doi: 10.1007/s00726-010-0773-2. Epub 2010 Oct 19.
9
Advanced glycation end products in foods and a practical guide to their reduction in the diet.
J Am Diet Assoc. 2010 Jun;110(6):911-16.e12. doi: 10.1016/j.jada.2010.03.018.
10
Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice.
J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):63-72.
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