University of Freiburg, Department of Neuropathology, Neurozentrum, Breisacher Str. 64 79106 Freiburg, Germany.
Trends Biochem Sci. 2011 Dec;36(12):625-32. doi: 10.1016/j.tibs.2011.08.008. Epub 2011 Oct 19.
The receptor for advanced glycation end products (RAGE) is a central signaling molecule in the innate immune system and is involved in the onset and sustainment of the inflammatory response. RAGE belongs to a class of pattern recognition receptors that recognize common features rather than a specific ligand. Recent structural information on the extracellular portion (ectodomain) of RAGE shed new light on this unusual ability. X-ray crystallographic, NMR and biochemical data suggest that ligand binding is driven largely by electrostatic interactions between the positively charged surface of the ectodomain and negatively charged ligands. In this article, I propose a putative mechanism of RAGE ligand recognition of receptor activation.
晚期糖基化终产物受体 (RAGE) 是先天免疫系统中的一个重要信号分子，参与炎症反应的发生和持续。RAGE 属于一类模式识别受体，它识别的是共同特征，而不是特定的配体。最近关于 RAGE 细胞外部分（胞外域）的结构信息为这种不寻常的能力提供了新的线索。X 射线晶体学、NMR 和生化数据表明，配体结合主要是由胞外域带正电荷的表面与带负电荷的配体之间的静电相互作用驱动的。在本文中，我提出了 RAGE 配体识别和受体激活的假设机制。
