昼夜节律和细胞因子在类风湿关节炎发病机制中的作用。
Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis.
机构信息
Faculty of Health Sciences, Kobe University School of Medicine, Kobe 654-0142, Japan.
Department of General Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, Japan.
出版信息
J Immunol Res. 2014;2014:282495. doi: 10.1155/2014/282495. Epub 2014 May 8.
Abstract
Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis.
摘要
在类风湿关节炎（RA）患者的症状中，关节僵硬受昼夜节律影响，在早晨达到高峰，这是一种常见的主诉，反映了疾病表现的昼夜节律性质。此外，早晨分泌达到高峰的炎症细胞因子是导致晨僵的主要因素。在这篇综述中，我们探讨了生物钟与炎症之间的联系，重点研究了各种生物钟基因与类风湿关节炎病理相关的免疫途径之间的相互作用。
相似文献
1
Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis.昼夜节律和细胞因子在类风湿关节炎发病机制中的作用。
J Immunol Res. 2014;2014:282495. doi: 10.1155/2014/282495. Epub 2014 May 8.
2
Reconsidering the Role of Melatonin in Rheumatoid Arthritis.重新思考褪黑素在类风湿关节炎中的作用。
Int J Mol Sci. 2020 Apr 20;21(8):2877. doi: 10.3390/ijms21082877.
3
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis.成纤维样滑膜细胞在关节炎中调控日常节律性炎症。
Open Biol. 2024 Jul;14(7):240089. doi: 10.1098/rsob.240089. Epub 2024 Jul 10.
4
The role of the circadian clock in rheumatoid arthritis.昼夜节律时钟在类风湿关节炎中的作用。
Arthritis Res Ther. 2013 Feb 21;15(1):205. doi: 10.1186/ar4146.
5
Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes.褪黑素在类风湿关节炎和骨关节炎炎症途径中的调节作用：昼夜节律钟基因的参与。
Br J Pharmacol. 2018 Aug;175(16):3230-3238. doi: 10.1111/bph.13898. Epub 2017 Jul 12.
6
Circadian timekeeping in Neurospora crassa and Synechococcus elongatus.Neurospora crassa 和 Synechococcus elongatus 的生物钟节律。
Essays Biochem. 2011 Jun 30;49(1):37-51. doi: 10.1042/bse0490037.
7
Interactions between the genes that regulate the body clock and those that worsen rheumatoid arthritis.调节生物钟的基因与那些会加重类风湿性关节炎的基因之间的相互作用。
Expert Rev Clin Immunol. 2010 Mar;6(2):181-3. doi: 10.1586/eci.10.3.
8
Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level.生物钟在类风湿关节炎中在分子水平上被打乱。
PLoS One. 2013;8(1):e54049. doi: 10.1371/journal.pone.0054049. Epub 2013 Jan 15.
9
Daily expression of clock genes in central and peripheral tissues of tree sparrow (Passer montanus).树麻雀（Passer montanus）中枢和外周组织中时钟基因的日常表达。
Chronobiol Int. 2019 Jan;36(1):110-121. doi: 10.1080/07420528.2018.1523185. Epub 2018 Oct 26.
10
Old and New Roles and Evolving Complexities of Cardiovascular Clocks.心血管钟的新旧角色和不断演变的复杂性。
Yale J Biol Med. 2019 Jun 27;92(2):283-290. eCollection 2019 Jun.
引用本文的文献
1
Single-cell RNA sequencing highlights the influence of innate and adaptive immune response mechanisms in psoriatic arthritis.单细胞RNA测序突出了先天性和适应性免疫反应机制在银屑病关节炎中的影响。
Front Immunol. 2025 Feb 27;15:1490051. doi: 10.3389/fimmu.2024.1490051. eCollection 2024.
2
The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation.心肌肌钙蛋白及其他新兴生物标志物在运动员及其他人群中的作用：潜在机制、鉴别诊断及解读指南
Biomolecules. 2024 Dec 19;14(12):1630. doi: 10.3390/biom14121630.
3
The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function .细胞因子受体Fn14是神经元活动的分子制动器，可介导昼夜节律功能。
bioRxiv. 2024 Apr 2:2024.04.02.587786. doi: 10.1101/2024.04.02.587786.
4
The Influence of Weather Conditions on the Diurnal Variation in Range of Motion in Older Adults with Knee Osteoarthritis.天气状况对老年膝骨关节炎患者运动范围昼夜变化的影响
J Clin Med. 2024 Jan 1;13(1):254. doi: 10.3390/jcm13010254.
5
Circadian Regulation of Macrophages and Osteoclasts in Rheumatoid Arthritis.类风湿关节炎中巨噬细胞和破骨细胞的昼夜节律调控。
Int J Mol Sci. 2023 Aug 1;24(15):12307. doi: 10.3390/ijms241512307.
6
Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances.长链非编码 RNA/环状 RNA 调控类风湿关节炎中的竞争性内源性 RNA 网络：分子机制和中药治疗意义。
Ann Med. 2023 Dec;55(1):973-989. doi: 10.1080/07853890.2023.2172605.
7
Chrono-moxibustion adjusts circadian rhythm of CLOCK and BMAL1 in adjuvant-induced arthritic rats.时辰艾灸调节佐剂诱导性关节炎大鼠中CLOCK和BMAL1的昼夜节律。
Am J Transl Res. 2022 Jul 15;14(7):4880-4897. eCollection 2022.
8
Reliability and validity of the Arabic version of the biological rhythms interview of assessment in neuropsychiatry.生物节律评估在神经精神医学中的访谈的阿拉伯语版本的可靠性和有效性。
Neuropsychopharmacol Rep. 2022 Sep;42(3):315-322. doi: 10.1002/npr2.12273. Epub 2022 Jun 13.
9
Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples.Clock 基因 mRNA 和 Clock 蛋白在人银屑病皮肤样本中的表达模式。
Int J Mol Sci. 2021 Dec 23;23(1):121. doi: 10.3390/ijms23010121.
10
Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway.Fascin1 通过 STAT3 通路介导类风湿关节炎中促炎细胞因子的释放及侵袭/迁移。
Cell Cycle. 2021 Nov;20(21):2210-2220. doi: 10.1080/15384101.2021.1974790. Epub 2021 Sep 9.
本文引用的文献
1
Morning melatonin serum values do not correlate with disease activity in rheumatoid arthritis: a cross-sectional study.晨血清褪黑素值与类风湿关节炎的疾病活动度无关：一项横断面研究。
Rheumatol Int. 2014 Aug;34(8):1145-51. doi: 10.1007/s00296-013-2930-x. Epub 2014 Feb 1.
2
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.节律钟基因 Rev-erbα 通过负向调控 Ccl2 表达来调节巨噬细胞的炎症功能。
J Immunol. 2014 Jan 1;192(1):407-17. doi: 10.4049/jimmunol.1301982. Epub 2013 Dec 4.
3
Sleep problems in patients with rheumatoid arthritis.类风湿关节炎患者的睡眠问题。
J Rheumatol. 2014 Jan;41(1):31-40. doi: 10.3899/jrheum.130430. Epub 2013 Dec 1.
4
Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates.在小鼠离体骨培养中进行的长时间生物发光监测显示，关节软骨和生长板中存在持久的昼夜节律。
PLoS One. 2013 Nov 4;8(11):e78306. doi: 10.1371/journal.pone.0078306. eCollection 2013.
5
Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.生物钟基因 Bmal1 调控 Ly6C(hi) 炎性单核细胞的昼夜节律波动。
Science. 2013 Sep 27;341(6153):1483-8. doi: 10.1126/science.1240636. Epub 2013 Aug 22.
6
Environmental circadian disruption elevates the IL-6 response to lipopolysaccharide in blood.环境昼夜节律紊乱会提高血液中脂多糖对白细胞介素 6 反应。
J Biol Rhythms. 2013 Aug;28(4):272-7. doi: 10.1177/0748730413494561.
7
The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis.小鼠软骨细胞中的生物钟调节着控制软骨稳态关键方面的基因。
Arthritis Rheum. 2013 Sep;65(9):2334-45. doi: 10.1002/art.38035.
8
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.REV-ERBs 通过抑制增强子指导的转录来抑制巨噬细胞基因表达。
Nature. 2013 Jun 27;498(7455):511-5. doi: 10.1038/nature12209. Epub 2013 Jun 2.
9
TNF-α modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells.TNF-α 调节类风湿性滑膜细胞中生物钟基因 Per2 的表达。
Scand J Rheumatol. 2013;42(4):276-80. doi: 10.3109/03009742.2013.765031. Epub 2013 Mar 16.
10
The role of the circadian clock in rheumatoid arthritis.昼夜节律时钟在类风湿关节炎中的作用。
Arthritis Res Ther. 2013 Feb 21;15(1):205. doi: 10.1186/ar4146.
Zotero 插件