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本文引用的文献

1
Morning melatonin serum values do not correlate with disease activity in rheumatoid arthritis: a cross-sectional study.晨血清褪黑素值与类风湿关节炎的疾病活动度无关：一项横断面研究。
Rheumatol Int. 2014 Aug;34(8):1145-51. doi: 10.1007/s00296-013-2930-x. Epub 2014 Feb 1.
2
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.节律钟基因 Rev-erbα 通过负向调控 Ccl2 表达来调节巨噬细胞的炎症功能。
J Immunol. 2014 Jan 1;192(1):407-17. doi: 10.4049/jimmunol.1301982. Epub 2013 Dec 4.
3
Sleep problems in patients with rheumatoid arthritis.类风湿关节炎患者的睡眠问题。
J Rheumatol. 2014 Jan;41(1):31-40. doi: 10.3899/jrheum.130430. Epub 2013 Dec 1.
4
Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates.在小鼠离体骨培养中进行的长时间生物发光监测显示，关节软骨和生长板中存在持久的昼夜节律。
PLoS One. 2013 Nov 4;8(11):e78306. doi: 10.1371/journal.pone.0078306. eCollection 2013.
5
Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.生物钟基因 Bmal1 调控 Ly6C(hi) 炎性单核细胞的昼夜节律波动。
Science. 2013 Sep 27;341(6153):1483-8. doi: 10.1126/science.1240636. Epub 2013 Aug 22.
6
Environmental circadian disruption elevates the IL-6 response to lipopolysaccharide in blood.环境昼夜节律紊乱会提高血液中脂多糖对白细胞介素 6 反应。
J Biol Rhythms. 2013 Aug;28(4):272-7. doi: 10.1177/0748730413494561.
7
The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis.小鼠软骨细胞中的生物钟调节着控制软骨稳态关键方面的基因。
Arthritis Rheum. 2013 Sep;65(9):2334-45. doi: 10.1002/art.38035.
8
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.REV-ERBs 通过抑制增强子指导的转录来抑制巨噬细胞基因表达。
Nature. 2013 Jun 27;498(7455):511-5. doi: 10.1038/nature12209. Epub 2013 Jun 2.
9
TNF-α modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells.TNF-α 调节类风湿性滑膜细胞中生物钟基因 Per2 的表达。
Scand J Rheumatol. 2013;42(4):276-80. doi: 10.3109/03009742.2013.765031. Epub 2013 Mar 16.
10
The role of the circadian clock in rheumatoid arthritis.昼夜节律时钟在类风湿关节炎中的作用。
Arthritis Res Ther. 2013 Feb 21;15(1):205. doi: 10.1186/ar4146.

昼夜节律和细胞因子在类风湿关节炎发病机制中的作用。

Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis.

机构信息

Faculty of Health Sciences, Kobe University School of Medicine, Kobe 654-0142, Japan.

Department of General Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, Japan.

出版信息

J Immunol Res. 2014;2014:282495. doi: 10.1155/2014/282495. Epub 2014 May 8.

DOI:10.1155/2014/282495
PMID:24901009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4034483/
Abstract

Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis.

摘要

在类风湿关节炎（RA）患者的症状中，关节僵硬受昼夜节律影响，在早晨达到高峰，这是一种常见的主诉，反映了疾病表现的昼夜节律性质。此外，早晨分泌达到高峰的炎症细胞因子是导致晨僵的主要因素。在这篇综述中，我们探讨了生物钟与炎症之间的联系，重点研究了各种生物钟基因与类风湿关节炎病理相关的免疫途径之间的相互作用。