Tomizawa Minoru, Shinozaki Fuminobu, Hasegawa Rumiko, Togawa Akira, Shirai Yoshinori, Ichiki Noboru, Motoyoshi Yasufumi, Sugiyama Takao, Yamamoto Shigenori, Sueishi Makoto
Hepatogastroenterology. 2014 Mar-Apr;61(130):291-5.
BACKGROUND/AIMS: The early diagnosis of acute cholangitis (AC) is critical for appropriate treatment.
Patient records from April 2008 to December 2012 were retrospectively analyzed. Data on white blood cell count and levels of C-reactive protein, total-bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (gamma-GTP) were collected from AC patients on the day they underwent endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and treatment. Data were collected 3 months before ERCP to analyze the rate of change of these variables. Receiver operating characteristics curve analysis was performed.
We enrolled 63 patients with AC and 65 patients with non-AC. The threshold values of ALP and gamma-GTP were 1.09 and 1.30, respectively.
450 (IU/L) and 100 (IU/L), respectively, were thresholds of ALP and gamma-GTP on the day of ERCP. 1.09 and 1.30, respectively, were thresholds of ALP and gamma-GTP rates of change for the diagnosis of AC.
背景/目的：急性胆管炎（AC）的早期诊断对于恰当治疗至关重要。
对2008年4月至2012年12月期间的患者记录进行回顾性分析。从接受内镜逆行胰胆管造影术（ERCP）进行诊断和治疗的AC患者身上收集白细胞计数以及C反应蛋白、总胆红素、碱性磷酸酶（ALP）、天冬氨酸氨基转移酶、丙氨酸氨基转移酶和γ-谷氨酰转肽酶（γ-GTP）水平的数据。在ERCP前3个月收集数据以分析这些变量的变化率。进行了受试者工作特征曲线分析。
我们纳入了63例AC患者和65例非AC患者。ALP和γ-GTP的阈值分别为1.09和1.30。
ERCP当天ALP和γ-GTP的阈值分别为450（IU/L）和100（IU/L）。诊断AC时ALP和γ-GTP变化率的阈值分别为1.09和1.30。
