Li Shunping, Wang Guimin, Xu Yanjiao, Gray Alastair, Chen Gang
*PhD †MSc ‡BN Centre for Health Management and Policy, Shandong University, Jinan, China (SL); Key Lab for Health Economics and Policy Research, Ministry of Health, Jinan, China (SL); Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China (GW, YX); Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (AG); and Flinders Health Economics Group, School of Medicine, Flinders University, Adelaide, Australia (GC).
Optom Vis Sci. 2014 Jul;91(7):723-9. doi: 10.1097/OPX.0000000000000299.
To elicit utility values of adult myopic patients in mainland China.
A valid sample of 442 myopia patients (spherical equivalent at least -0.5 diopters) aged 17 to 44 years who were scheduled to undergo refractive surgery were recruited. Information on time trade-off ([TTO] years of life willing to sacrifice for treatment of myopia) and standard gamble (SG) for blindness (risk of blindness from therapy, willing to sacrifice for treatment of myopia) utility values and sociodemographic and clinical data were obtained.
The mean utility values based on TTO and SG were 0.96 ± 0.05 (95% confidence interval [CI], 0.95 to 0.96; median, 0.98) and 0.93 ± 0.09 (95% CI, 0.92 to 0.94; median, 0.97), respectively. Myopic patients using contact lens had significantly higher TTO utility values than those wearing glasses (p < 0.001). There was no significant difference in the TTO and SG utility values by age, sex, occupation, educational levels, residence, reasons for refractive surgery, and severity and duration of myopia (p > 0.05).
The TTO and SG produce similar mean utility values, but there is poor agreement between results for individuals from the two methods. Utility values associated with myopic patients obtained in this study or reported in the literature seem to be higher than those obtained for other ophthalmic conditions.
获取中国大陆成年近视患者的效用值。
招募了442例年龄在17至44岁之间、计划接受屈光手术的近视患者（等效球镜至少为-0.5屈光度）作为有效样本。获取了关于时间权衡法（[TTO]愿意为治疗近视而牺牲的生命年数）和失明的标准博弈法（SG）（治疗导致失明的风险、愿意为治疗近视而牺牲的情况）效用值以及社会人口统计学和临床数据。
基于时间权衡法和标准博弈法的平均效用值分别为0.96±0.05（95%置信区间[CI]，0.95至0.96；中位数，0.98）和0.93±0.09（95%CI，0.92至0.94；中位数，0.97）。使用隐形眼镜的近视患者的时间权衡法效用值显著高于戴眼镜的患者（p<0.001）。按年龄、性别、职业、教育水平、居住地、屈光手术原因以及近视的严重程度和病程划分，时间权衡法和标准博弈法的效用值无显著差异（p>0.05）。
时间权衡法和标准博弈法得出的平均效用值相似，但两种方法对个体的结果一致性较差。本研究中获得的或文献中报道的与近视患者相关的效用值似乎高于其他眼科疾病的效用值。
