Zeytin Kayhan, Ciloğlu Nesibe Sinem, Ateş Filiz, Vardar Aker Fugen, Ercan Feriha
Department of Plastic Surgery, Manisa State Hospital, Manisa, Turkey.
Department of Plastic, Reconstructive and Aesthetic Surgery, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Acta Orthop Traumatol Turc. 2014;48(3):355-62. doi: 10.3944/AOTT.2014.13.0096.
The aim of this study was to determine the effects of resveratrol on the tendon healing process of streptozotocin-induced diabetic rats.
The study included 16 male Sprague-Dawley rats. Streptozotocin was administered to induce diabetes and bilateral tenorrhaphy of the Achilles tendons was performed. Intraperitoneal resveratrol was injected in the experimental group (n=8) and saline in the control group (n=8) during the postoperative period. Rats were sacrificed at the 14th day. Right side tendons were evaluated biomechanically and left side tendons histologically.
Difference in mean tendon tensile strength was not statistically significant between groups (p>0.05). Histologic evaluations of the repair zones showed greater configuration of the newly synthesized collagen in the experimental group. The ratio of the newly synthesized collagen area to the healing region area was significantly higher in the experimental group then the control group (p<0.01).
Resveratrol appears to have a positive impact on the process of tendon healing in diabetic conditions in the first 14 days.
本研究旨在确定白藜芦醇对链脲佐菌素诱导的糖尿病大鼠肌腱愈合过程的影响。
该研究纳入了16只雄性斯普拉格-道利大鼠。给予链脲佐菌素诱导糖尿病，并对双侧跟腱进行缝合。术后期间，实验组（n = 8）腹腔注射白藜芦醇，对照组（n = 8）腹腔注射生理盐水。在第14天处死大鼠。右侧肌腱进行生物力学评估，左侧肌腱进行组织学评估。
两组间平均肌腱拉伸强度差异无统计学意义（p>0.05）。修复区的组织学评估显示，实验组新合成胶原蛋白的形态更好。实验组新合成胶原蛋白面积与愈合区域面积的比值显著高于对照组（p<0.01）。
在最初的14天里，白藜芦醇似乎对糖尿病状态下的肌腱愈合过程有积极影响。
