Department of Dermatology, Inserm U905, Institute for Research and Innovation in Biomedicine, Rouen University Hospital, University of Normandy, Rouen, France.
Br J Dermatol. 2014 Sep;171(3):580-7. doi: 10.1111/bjd.13155. Epub 2014 Aug 11.
The incidence of myocardial events has been reported to be increased in patients with psoriasis.
To investigate whether psoriasis is an independent risk factor for coronary artery disease (CAD).
We compared the prevalence of psoriasis between case patients with a diagnosis of CAD based on coronary angiography findings and control patients with no CAD referred to the emergency surgery department for an acute noncardiovascular condition. Case and control patients were examined for the presence of psoriasis by two dermatologists. The prevalence of psoriasis was compared among patients with CAD according to CAD severity. Five-hundred cases and 500 age- and sex-matched controls were included.
Using matched univariate analysis, the prevalence of psoriasis was about twofold higher in CAD case patients than in control patients [8·0% vs. 3·4%, odds ratio (OR) 2·64; 95% confidence interval (CI) 1·42-4·88]. Using unconditional multivariate analysis, the association of psoriasis with CAD appeared to be borderline significant (OR 1·84; 95% CI 0·99-3·40). Psoriasis in patients with CAD was significantly associated with three-vessel involvement relative to one-or two-vessel involvement (13·1% vs. 6·1%; OR 3·07; 95% CI 1·50-6·25).
The prevalence of psoriasis is twofold higher in patients with CAD than in control patients without CAD. It is associated with a more severe coronary artery involvement.
据报道，银屑病患者心肌事件的发生率增加。
研究银屑病是否是冠心病（CAD）的独立危险因素。
我们比较了基于冠状动脉造影结果诊断为 CAD 的病例患者和因急性非心血管疾病就诊于急诊外科的无 CAD 的对照患者中银屑病的患病率。由两名皮肤科医生对病例和对照患者进行银屑病检查。根据 CAD 严重程度比较 CAD 患者中银屑病的患病率。纳入 500 例病例和 500 名年龄和性别匹配的对照患者。
采用匹配的单因素分析，CAD 病例患者中银屑病的患病率约为对照患者的两倍[8.0%比 3.4%，优势比（OR）2.64；95%置信区间（CI）1.42-4.88]。采用无条件多因素分析，银屑病与 CAD 的关联似乎具有边缘显著性（OR 1.84；95%CI 0.99-3.40）。与单支或两支血管受累相比，CAD 患者的银屑病与三支血管受累明显相关（13.1%比 6.1%；OR 3.07；95%CI 1.50-6.25）。
银屑病在 CAD 患者中的患病率是无 CAD 的对照患者的两倍。它与更严重的冠状动脉受累有关。
