1. Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China;
2. Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China;
Int J Med Sci. 2014 May 15;11(7):754-7. doi: 10.7150/ijms.8059. eCollection 2014.
Cyclin A1 belongs to the type-A cyclins and participates in cell cycle regulation. Since its discovery, cyclin A1 has been shown mostly in testis. It plays important roles in spermatogenesis. However, there were also reports on ovary expression of cyclin A1. Therefore, we intended to revisit the expression of cyclin A1 in mouse ovary. Our study showed that cyclin A1 was expressed at the mRNA level and the protein level in mouse ovary. Tissue staining revealed that cyclin A1 was expressed in maturating oocytes. With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells. Our findings not only add to the supportive evidence of cyclin A1 expression in oocytes, but also may promote more interest in exploring cyclin A1 functions in ovary.
细胞周期蛋白 A1 属于 A 型细胞周期蛋白，参与细胞周期调控。自发现以来，细胞周期蛋白 A1 主要存在于睾丸中。它在精子发生中发挥重要作用。然而，也有关于细胞周期蛋白 A1 在卵巢中表达的报道。因此，我们旨在重新研究细胞周期蛋白 A1 在小鼠卵巢中的表达。我们的研究表明，细胞周期蛋白 A1 在小鼠卵巢中mRNA 水平和蛋白水平上均有表达。组织染色显示细胞周期蛋白 A1 在成熟卵母细胞中表达。鉴于最近关于细胞周期蛋白在体细胞和干细胞中的功能的数据，我们还讨论了进一步研究细胞周期蛋白 A1 在小鼠卵母细胞中的可能性，也许还可以研究卵原细胞中的干细胞。我们的发现不仅为卵母细胞中细胞周期蛋白 A1 的表达提供了更多支持证据，还可能促进更多人对探索细胞周期蛋白 A1 在卵巢中的功能产生兴趣。
