Muro A, Cordero M, Martín J, Simón F
Enferm Infecc Microbiol Clin. 1989 Dec;7(10):542-3.
The development of an immunoenzymatic technique for the detection of specific IgG against Dirofilaria immitis in humans is reported. Two groups of rabbits were used as controls; one of them was hyperimmunized with D. immitis antigens and the other was not inoculated. Subsequently, the reactivity to D. immitis and T. canis of the sera of three patients with pulmonary nodules and 25 apparently healthy individuals was evaluated. In two of the patients with pulmonary nodules the reactivity against D. immitis was significantly higher than that of healthy individuals. Reactivity against T. canis was not found in any case. These initial results seem to indicate that, in the reported conditions, this technique could prevent crossed reactions between D. immitis and T. canis and could help in the differential diagnosis of other causes of pulmonary nodules.
本文报道了一种用于检测人体抗犬恶丝虫特异性IgG的免疫酶技术的开发。使用两组兔子作为对照；其中一组用犬恶丝虫抗原进行超免疫，另一组未接种。随后，评估了3例肺结节患者和25名明显健康个体血清对犬恶丝虫和犬弓首蛔虫的反应性。在2例肺结节患者中，对犬恶丝虫的反应性明显高于健康个体。在任何情况下均未发现对犬弓首蛔虫的反应性。这些初步结果似乎表明，在报告的条件下，该技术可以防止犬恶丝虫和犬弓首蛔虫之间的交叉反应，并有助于肺结节其他病因的鉴别诊断。
