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Allen 脑图谱驱动的可视化:一个基于网络的基因表达能量可视化工具。

Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool.

机构信息

Department of Cognitive Sciences, University of California, Irvine Irvine, CA, USA.

Department of Cognitive Sciences, University of California, Irvine Irvine, CA, USA ; Department of Computer Science, University of California, Irvine Irvine, CA, USA.

出版信息

Front Neuroinform. 2014 May 21;8:51. doi: 10.3389/fninf.2014.00051. eCollection 2014.

Abstract

The Allen Brain Atlas-Driven Visualizations (ABADV) is a publicly accessible web-based tool created to retrieve and visualize expression energy data from the Allen Brain Atlas (ABA) across multiple genes and brain structures. Though the ABA offers their own search engine and software for researchers to view their growing collection of online public data sets, including extensive gene expression and neuroanatomical data from human and mouse brain, many of their tools limit the amount of genes and brain structures researchers can view at once. To complement their work, ABADV generates multiple pie charts, bar charts and heat maps of expression energy values for any given set of genes and brain structures. Such a suite of free and easy-to-understand visualizations allows for easy comparison of gene expression across multiple brain areas. In addition, each visualization links back to the ABA so researchers may view a summary of the experimental detail. ABADV is currently supported on modern web browsers and is compatible with expression energy data from the Allen Mouse Brain Atlas in situ hybridization data. By creating this web application, researchers can immediately obtain and survey numerous amounts of expression energy data from the ABA, which they can then use to supplement their work or perform meta-analysis. In the future, we hope to enable ABADV across multiple data resources.

摘要

艾伦脑图谱驱动的可视化(ABADV)是一个公开访问的基于网络的工具,用于从艾伦脑图谱(ABA)中检索和可视化多个基因和脑结构的表达能量数据。尽管 ABA 为研究人员提供了自己的搜索引擎和软件,用于查看他们不断增长的在线公共数据集,包括来自人类和小鼠大脑的广泛基因表达和神经解剖数据,但他们的许多工具限制了研究人员一次可以查看的基因和脑结构数量。为了补充他们的工作,ABADV 生成了多个饼图、柱状图和热图,用于任何给定的基因和脑结构集的表达能量值。这样一套免费且易于理解的可视化工具可方便地比较多个脑区的基因表达情况。此外,每个可视化都链接回 ABA,以便研究人员可以查看实验细节的摘要。ABADV 目前在现代网络浏览器上得到支持,并与 Allen Mouse Brain Atlas in situ 杂交数据的表达能量数据兼容。通过创建这个网络应用程序,研究人员可以立即从 ABA 中获得和调查大量的表达能量数据,然后可以将其用于补充他们的工作或进行元分析。未来,我们希望在多个数据资源中启用 ABADV。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0d1/4033128/7e3fdc27608d/fninf-08-00051-g0001.jpg

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