Hentges François, Léonard Cathy, Arumugam Karthik, Hilger Christiane
Laboratory of Immunogenetics and Allergology, CRP-Santé , Luxembourg , Luxembourg.
Laboratory of Retrovirology, CRP-Santé , Luxembourg , Luxembourg.
Front Immunol. 2014 May 21;5:234. doi: 10.3389/fimmu.2014.00234. eCollection 2014.
In Europe and the USA, at least one person in four is exposed every day to inhalant allergens of mammalian origin, a considerable number is regularly exposed for professional reasons and almost everyone is occasionally exposed to inhalant allergens from pets or domestic animals. The production of IgE to these inhalant allergens, often complicated by asthma and rhinitis, defines the atopic status. However, the immune response to these allergens largely imprints the cellular immune compartment and also drives non-IgE humoral immune responses in the allergic and non-allergic population. During the recent years, it has become clear that IgE antibodies recognize mammalian allergens that belong to three protein or glycoprotein families: the secretoglobins, the lipocalins, and the serum albumins. In this article, we review the humoral and cellular immune responses to the major members of these families and try to define common characteristics and also distinctive features.
在欧洲和美国，每天至少四分之一的人会接触到源自哺乳动物的吸入性变应原，相当一部分人因职业原因经常接触，几乎每个人偶尔都会接触到来自宠物或家畜的吸入性变应原。针对这些吸入性变应原产生的IgE，常伴有哮喘和鼻炎，这定义了特应性状态。然而，对这些变应原的免疫反应在很大程度上影响了细胞免疫区室，并且在过敏和非过敏人群中也驱动了非IgE体液免疫反应。近年来，已经明确IgE抗体识别属于三个蛋白质或糖蛋白家族的哺乳动物变应原：分泌球蛋白、脂质运载蛋白和血清白蛋白。在本文中，我们综述了对这些家族主要成员的体液和细胞免疫反应，并试图确定其共同特征和独特特征。
