Department of Anatomy, Faculty of Medicine, Cairo University, Egypt.
Arch Med Sci. 2014 May 12;10(2):381-8. doi: 10.5114/aoms.2012.28807. Epub 2012 May 29.
Indomethacin is a non steroidal anti-inflammatory drug (NSAID) which is capable of producing injury to gastric mucosa. To prevent of NSAID-induced gastropathy, it is important to evaluate the risk factors. One of them is steroid. The aim is to study time dependent effects of glucocorticoids (GC) on indomethacin induced gastric ulcer.
Forty-nine albino rats were used. They were divided into control and experimental groups. The experimental group was subgroup I (rats were given indomethacin and were sacrificed 1 day after drug intake), subgroup II (rats were given indomethacin + dexamethasone and were sacrificed 1 day after drug intake), subgroup III (rats were given indomethacin + dexamethasone and were sacrificed 3 days after drug intake) and subgroup IV (rats were given indomethacin + dexamethasone and were sacrificed 7 days day after drug intake). Histological, scanning electron microscopy and morphometric studies were used.
Indomethacin induced gastric ulceration with shredding of the superficial epithelial cells. The fundic glands were dilated in the subgroups II, III, IV. The surface epithelial cells were shredded and the ulcer sizes were big in subgroup IV. All subgroups exhibited abnormal surface epithelial cells within the gastric ulcer area.
Indomethacin is capable of producing injury to gastrointestinal mucosa. With prolonged use of GC the surface epithelial cells became more affected and the ulcer sizes became bigger. Concomitant use of both medications will delay the healing of the indomethacin induced gastric ulcer and induce more gastric complication.
吲哚美辛是一种非甾体抗炎药（NSAID），能够对胃黏膜造成损伤。为了预防 NSAID 引起的胃病，评估相关风险因素很重要。其中一个因素是类固醇。本研究旨在研究糖皮质激素（GC）对吲哚美辛诱导的胃溃疡的时间依赖性影响。
使用 49 只白化大鼠。它们被分为对照组和实验组。实验组又分为亚组 I（大鼠给予吲哚美辛，在药物摄入后 1 天被处死）、亚组 II（大鼠给予吲哚美辛+地塞米松，在药物摄入后 1 天被处死）、亚组 III（大鼠给予吲哚美辛+地塞米松，在药物摄入后 3 天被处死）和亚组 IV（大鼠给予吲哚美辛+地塞米松，在药物摄入后 7 天被处死）。进行了组织学、扫描电子显微镜和形态计量学研究。
吲哚美辛引起胃黏膜溃疡，导致表面上皮细胞剥落。在亚组 II、III、IV 中，胃底腺扩张。表面上皮细胞剥落，溃疡面积在亚组 IV 中较大。所有亚组在胃溃疡区域均表现出异常的表面上皮细胞。
吲哚美辛能够对胃肠道黏膜造成损伤。GC 的长期使用会使表面上皮细胞受到更大的影响，溃疡面积也会更大。同时使用这两种药物会延迟吲哚美辛诱导的胃溃疡的愈合，并引起更多的胃并发症。
