Department of Biomaterial Control, Dong-Eui University, Busan 614-714, Korea.
J Microbiol Biotechnol. 2011 Apr;21(4):400-4.
Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions. In this study, we investigated the effect of selenium on gastric mucosal lesions in rats. To confirm the curative effect of selenium against indomethacin-induced gastric ulcers, gastric ulcers were induced by oral administration of 25 mg/kg indomethacin, and then different doses (10, 50, and 100 microgram/kg of body weight) of selenium or vehicle were treated by oral gavage for 3 days. Oral administration of indomethacin clearly increased the gastric ulcer area in the stomach, whereas selenium applied for 3 days significantly decreased the gastric ulcer area in a dose-dependent manner. In addition, selenium markedly reduced the increase of lipid peroxidation induced by indomethacin in the gastric mucosa and increased activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. These results reveal that selenium can heal indomethacininduced gastric ulcers through elimination of the lipid peroxides and activation of radical scavenging enzymes.
吲哚美辛是一种非甾体类抗炎药，已知其可导致严重的胃黏膜损伤。在本研究中，我们研究了硒对大鼠胃黏膜损伤的影响。为了证实硒对吲哚美辛诱导的胃溃疡的治疗作用，通过口服给予 25mg/kg 吲哚美辛诱导胃溃疡，然后通过口服灌胃给予不同剂量（10、50 和 100μg/kg 体重）的硒或载体 3 天。吲哚美辛的口服给药明显增加了胃中的胃溃疡面积，而硒在 3 天内的应用则以剂量依赖的方式显著降低了胃溃疡面积。此外，硒显著减少了吲哚美辛诱导的胃黏膜脂质过氧化的增加，并以剂量依赖的方式增加了超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等自由基清除酶的活性。这些结果表明，硒可以通过消除脂质过氧化物和激活自由基清除酶来治愈吲哚美辛诱导的胃溃疡。
