Simon Doerte, Becker Michael P I, Mothes-Lasch Martin, Miltner Wolfgang H R, Straube Thomas
Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Germany.
Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Germany.
Neuroimage. 2014 Oct 1;99:1-6. doi: 10.1016/j.neuroimage.2014.05.071. Epub 2014 Jun 3.
It is now well established that activation of the ventral striatum (VS) encodes feedback related information, in particular, aspects of feedback validity, reward magnitude, and reward probability. More recent findings also point toward a role of VS in encoding social context of feedback processing. Here, we investigated the effect of social observation on neural correlates of feedback processing. To this end, subjects performed a time estimation task and received positive, negative, or uninformative feedback. In one half of the experiment subjects thought that an experimenter closely monitored their face via a camera. We successfully replicated an elevated VS response to positive relative to negative feedback. Further, our data demonstrate that this reward-related activation of the VS is increased during observation by others. Using uninformative feedback as reference condition, we show that specifically VS activation during positive feedback was modulated by observation manipulation. Our findings support accounts which posit a role of VS in integrating social context into the processing of feedback and, in doing so, signaling its social relevance.
现已充分证实，腹侧纹状体（VS）的激活编码与反馈相关的信息，特别是反馈有效性、奖励大小和奖励概率等方面。最近的研究结果还表明，VS在编码反馈处理的社会背景方面发挥作用。在此，我们研究了社会观察对反馈处理神经相关性的影响。为此，受试者执行了一项时间估计任务，并收到正面、负面或无信息反馈。在实验的一半过程中，受试者认为一名实验者通过摄像头密切监视他们的面部。我们成功复制了VS对正面反馈相对于负面反馈的增强反应。此外，我们的数据表明，在他人观察期间，VS这种与奖励相关的激活会增加。以无信息反馈作为参考条件，我们表明，在正面反馈期间，VS的激活特别受到观察操作的调节。我们的研究结果支持了这样的观点，即VS在将社会背景整合到反馈处理中并以此表明其社会相关性方面发挥作用。
