Li Haoquan, Li Wanfang, Spannenberg Anke, Baumann Wolfgang, Neumann Helfried, Beller Matthias, Wu Xiao-Feng
Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert-Einstein-Strasse 29a, 18059 Rostock (Germany).
Chemistry. 2014 Jul 7;20(28):8541-4. doi: 10.1002/chem.201403417. Epub 2014 Jun 6.
Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2-b]quinazoline-10,12-diones. At least five different CC and/or CN bonds are selectively formed in this 3-component reaction, which likely proceeds through sequential carbonylation-cyclization-isomerisation-carbonylation steps. Notably, two molecules of CO are inserted in this highly efficient palladium-catalyzed process.
在一个新颖的双羰基化过程中，将市售的溴苯胺和溴苯腈结合起来，可以直接合成异吲哚并[1,2 - b]喹唑啉 - 10,12 - 二酮。在这个三组分反应中，至少有五种不同的CC和/或CN键被选择性地形成，该反应可能通过连续的羰基化 - 环化 - 异构化 - 羰基化步骤进行。值得注意的是，在这个高效的钯催化过程中插入了两分子的CO。
