State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue, Guangzhou 510530, China.
Org Lett. 2014 May 16;16(10):2748-51. doi: 10.1021/ol501070g. Epub 2014 May 7.
An efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-one through palladium-catalyzed C(sp(2))-H pyridocarbonylation of N-aryl-2-aminopyridines has been developed. The pyridyl group acts as an intramolecular nucleophile for the first time in C-H carbonylation reactions.
通过钯催化的 N-芳基-2-氨基吡啶的 C(sp(2))-H 吡啶甲酰化反应，高效合成了 11H-吡啶并[2,1-b]喹唑啉-11-酮。吡啶基首次作为亲核试剂参与到 C-H 羰基化反应中。
