Huelsmann Sven, Brown Nicholas H
The Gurdon Institute and Department of Physiology, Development, and Neuroscience; University of Cambridge; Cambridge, UK; Department of Biological and Environmental Science; University of Jyväskylä; Jyväskylä, Finland.
The Gurdon Institute and Department of Physiology, Development, and Neuroscience; University of Cambridge; Cambridge, UK.
Nucleus. 2014 May-Jun;5(3):219-23. doi: 10.4161/nucl.29405. Epub 2014 Jun 6.
Nuclear positioning is an important process during development and homeostasis. Depending on the affected tissue, mislocalized nuclei can alter cellular processes such as polarization, differentiation, or migration and lead ultimately to diseases. Many cells actively control the position of their nucleus using their cytoskeleton and motor proteins. We have recently shown that during Drosophila oogenesis, nurse cells employ cytoplasmic actin cables in association with perinuclear actin to position their nucleus. Here, we briefly summarize our work and discuss why nuclear positioning in nurse cells is specialized but the molecular mechanisms are likely to be more generally used.
细胞核定位是发育和体内平衡过程中的一个重要过程。根据受影响的组织不同，细胞核定位错误会改变细胞过程，如极化、分化或迁移，并最终导致疾病。许多细胞利用其细胞骨架和运动蛋白来主动控制细胞核的位置。我们最近发现，在果蝇卵子发生过程中，营养细胞利用细胞质肌动蛋白电缆与核周肌动蛋白结合来定位其细胞核。在这里，我们简要总结我们的工作，并讨论为什么营养细胞中的细胞核定位是特殊的，但分子机制可能更广泛地被使用。
