将“金标准”应用于体外衍生的生殖细胞。
Applying "gold standards" to in-vitro-derived germ cells.
作者信息
Handel Mary Ann, Eppig John J, Schimenti John C
机构信息
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
出版信息
Cell. 2014 Jun 5;157(6):1257-1261. doi: 10.1016/j.cell.2014.05.019.
Abstract
Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.
摘要
生殖细胞是终极干细胞，其体外诱导的相关报道因在生殖医学中的潜在应用而引发关注。迄今为止，尚无确凿证据表明减数分裂（配子发生的标志）能在性腺外被如实地复制。我们提出了评估生殖细胞体外诱导的基准，以促进其潜能的实现。
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