将“金标准”应用于体外衍生的生殖细胞。
Applying "gold standards" to in-vitro-derived germ cells.
作者信息
Handel Mary Ann, Eppig John J, Schimenti John C
机构信息
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
出版信息
Cell. 2014 Jun 5;157(6):1257-1261. doi: 10.1016/j.cell.2014.05.019.
Abstract
Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.
摘要
生殖细胞是终极干细胞，其体外诱导的相关报道因在生殖医学中的潜在应用而引发关注。迄今为止，尚无确凿证据表明减数分裂（配子发生的标志）能在性腺外被如实地复制。我们提出了评估生殖细胞体外诱导的基准，以促进其潜能的实现。
相似文献
1
Applying "gold standards" to in-vitro-derived germ cells.
Cell. 2014 Jun 5;157(6):1257-1261. doi: 10.1016/j.cell.2014.05.019.
2
Reconstitution of gametogenesis in vitro: meiosis is the biggest obstacle.
J Genet Genomics. 2014 Mar 20;41(3):87-95. doi: 10.1016/j.jgg.2013.12.008. Epub 2014 Feb 22.
3
Stem Cell-Derived Human Gametes: The Public Engagement Imperative.
Trends Mol Med. 2019 Mar;25(3):165-167. doi: 10.1016/j.molmed.2019.01.005. Epub 2019 Feb 6.
4
[Advances in the study of the differentiation of stem cells into male gametes].
Zhonghua Nan Ke Xue. 2011 Apr;17(4):356-60.
5
Primordial germ cell biology at the beginning of the XXI century.
Int J Dev Biol. 2009;53(7):891-4. doi: 10.1387/ijdb.082815mf.
6
In vitro reconstitution of germ cell development†.
Biol Reprod. 2019 Sep 1;101(3):567-578. doi: 10.1093/biolre/ioz111.
7
Derivation of embryonic germ cells and male gametes from embryonic stem cells.
Nature. 2004 Jan 8;427(6970):148-54. doi: 10.1038/nature02247. Epub 2003 Dec 10.
8
[Progress in the research of germ cell from human embryonic stem cells].
Sheng Li Ke Xue Jin Zhan. 2006 Jan;37(1):17-21.
9
Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling.
PLoS Genet. 2015 Mar 4;11(3):e1005019. doi: 10.1371/journal.pgen.1005019. eCollection 2015 Mar.
10
Germ cells in the teleost fish medaka have an inherent feminizing effect.
PLoS Genet. 2018 Mar 29;14(3):e1007259. doi: 10.1371/journal.pgen.1007259. eCollection 2018 Mar.
引用本文的文献
1
A new human model of cytotypic and testosterone-producing organoids derived from testicular tissue of transgender women.
Hum Reprod Open. 2025 Aug 20;2025(3):hoaf043. doi: 10.1093/hropen/hoaf043. eCollection 2025.
2
Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors.
Sci Adv. 2025 Aug 15;11(33):eadu0384. doi: 10.1126/sciadv.adu0384.
3
Elucidating the Transcriptional States of Spermatogenesis-Joint Analysis of Germline and Supporting Cell, Mice and Human, Normal and Perturbed, Bulk and Single-Cell RNA-Seq.
Biomolecules. 2024 Jul 12;14(7):840. doi: 10.3390/biom14070840.
4
Spermatogonial stem cell technologies: applications from human medicine to wildlife conservation†.
Biol Reprod. 2024 Oct 14;111(4):757-779. doi: 10.1093/biolre/ioae109.
5
Induction of Meiosis from Human Pluripotent Stem Cells.
bioRxiv. 2024 May 31:2024.05.31.596483. doi: 10.1101/2024.05.31.596483.
6
Induction of Meiotic Initiation in Long-Term Mouse Spermatogonial Stem Cells Under Retinoid Acid and Nutrient Restriction Conditions.
Methods Mol Biol. 2024;2770:113-121. doi: 10.1007/978-1-0716-3698-5_9.
7
Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis.
Stem Cell Res Ther. 2023 Sep 21;14(1):262. doi: 10.1186/s13287-023-03466-6.
8
Ovarian aging: mechanisms and intervention strategies.
Med Rev (2021). 2022 Nov 22;2(6):590-610. doi: 10.1515/mr-2022-0031. eCollection 2022 Dec.
9
Modeling Human Gonad Development in Organoids.
Tissue Eng Regen Med. 2022 Dec;19(6):1185-1206. doi: 10.1007/s13770-022-00492-y. Epub 2022 Nov 9.
10
Suppression of trinucleotide repeat expansion in spermatogenic cells in Huntington's disease.
J Assist Reprod Genet. 2022 Oct;39(10):2413-2430. doi: 10.1007/s10815-022-02594-x. Epub 2022 Sep 6.
本文引用的文献
1
Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules.
Cell Rep. 2014 May 22;7(4):1284-97. doi: 10.1016/j.celrep.2014.03.067. Epub 2014 May 1.
2
RNA sequencing-based identification of aberrant imprinting in cloned mice.
Hum Mol Genet. 2014 Feb 15;23(4):992-1001. doi: 10.1093/hmg/ddt495. Epub 2013 Oct 8.
3
Induction of mouse germ-cell fate by transcription factors in vitro.
Nature. 2013 Sep 12;501(7466):222-6. doi: 10.1038/nature12417. Epub 2013 Aug 4.
4
No evidence for neo-oogenesis may link to ovarian senescence in adult monkey.
Stem Cells. 2013 Nov;31(11):2538-50. doi: 10.1002/stem.1480.
5
Oocyte differentiation is genetically dissociable from meiosis in mice.
Nat Genet. 2013 Aug;45(8):877-83. doi: 10.1038/ng.2672. Epub 2013 Jun 16.
6
Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles.
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8585-90. doi: 10.1073/pnas.1306189110. Epub 2013 Apr 29.
7
Mitosis-meiosis and sperm-oocyte fate decisions are separable regulatory events.
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3411-6. doi: 10.1073/pnas.1300928110. Epub 2013 Feb 11.
8
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Science. 2012 Nov 16;338(6109):971-5. doi: 10.1126/science.1226889. Epub 2012 Oct 4.
9
Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future.
Reprod Sci. 2013 Jan;20(1):7-15. doi: 10.1177/1933719112462632. Epub 2012 Sep 27.
10
Genetics of meiosis and recombination in mice.
Int Rev Cell Mol Biol. 2012;298:179-227. doi: 10.1016/B978-0-12-394309-5.00005-5.
Zotero 插件