García-Arenzana J M, Urbieta M, Idígoras P, Pérez-Trallero E
Enferm Infecc Microbiol Clin. 1989 Apr;7(4):195-8.
General hospitals should not ignore tropical diseases, even if they are not directly concerned with them. In our area, 3 and 6 instances of malaria have been diagnosed per year, 13 cases having been observed during the last 3 years. Prognosis is related with the quickness in achieving the diagnosis after the onset of symptoms; in our series it ranged from 4 days and one month. The outcome was good in all cases. To keep a reasonable good suspicion level, it should be remembered that the latency period between the infection and the development of symptoms may be very long. In 4 patients, the symptoms began 6 or more months after the patient had returned from the endemic zone. Chemoprophylaxis does not prevent the development of the disease in all individuals, although it is an effective prophylactic measure. Eight of these 13 patients had not undergone chemoprophylaxis or it had been incorrect. There was a remarkably high rate of patients infected by Pl. falciparum strains with in vivo resistance to antimalarial agents (chloroquine and fansidar).
综合医院不应忽视热带疾病，即便它们与热带疾病并无直接关联。在我们所在地区，每年诊断出3至6例疟疾，过去3年共观察到13例。预后与症状出现后确诊的速度有关；在我们的病例系列中，这一过程为4天至1个月不等。所有病例的预后良好。为保持合理的高度怀疑水平，应记住感染与症状出现之间的潜伏期可能非常长。在4例患者中，症状在其从流行区返回6个月或更长时间后才开始出现。化学预防虽为有效预防措施，但并不能防止所有个体发病。这13例患者中有8例未进行化学预防或预防方法不当。感染对抗疟药（氯喹和磺胺多辛-乙胺嘧啶）具有体内抗性的恶性疟原虫菌株的患者比例极高。
