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植物基因组中的结构变异

Structural variations in plant genomes.

作者信息

Saxena Rachit K, Edwards David, Varshney Rajeev K

出版信息

Brief Funct Genomics. 2014 Jul;13(4):296-307. doi: 10.1093/bfgp/elu016. Epub 2014 Jun 6.

Abstract

Differences between plant genomes range from single nucleotide polymorphisms to large-scale duplications, deletions and rearrangements. The large polymorphisms are termed structural variants (SVs). SVs have received significant attention in human genetics and were found to be responsible for various chronic diseases. However, little effort has been directed towards understanding the role of SVs in plants. Many recent advances in plant genetics have resulted from improvements in high-resolution technologies for measuring SVs, including microarray-based techniques, and more recently, high-throughput DNA sequencing. In this review we describe recent reports of SV in plants and describe the genomic technologies currently used to measure these SVs.

摘要

植物基因组之间的差异范围从单核苷酸多态性到大规模的重复、缺失和重排。这些大的多态性被称为结构变异(SVs)。结构变异在人类遗传学中受到了广泛关注,并被发现与多种慢性疾病有关。然而,对于了解结构变异在植物中的作用,人们所做的努力很少。植物遗传学领域最近的许多进展都得益于测量结构变异的高分辨率技术的改进,包括基于微阵列的技术,以及最近的高通量DNA测序技术。在这篇综述中,我们描述了植物中结构变异的最新报道,并介绍了目前用于测量这些结构变异的基因组技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6ff/4110416/d73fee6b71c9/elu016f1p.jpg

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