Carbone Erica J, Jiang Tao, Nelson Clarke, Henry Nicole, Lo Kevin W-H
Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Nanomedicine. 2014 Nov;10(8):1691-9. doi: 10.1016/j.nano.2014.05.013. Epub 2014 Jun 5.
Musculoskeletal regenerative engineering approach using small bioactive molecules in conjunction with advanced materials has emerged as a highly promising strategy for musculoskeletal repair and regeneration. Advanced biomaterials technologies have revealed nanofiber-based scaffolds for musculoskeletal tissue engineering as vehicles for the controlled delivery of small molecule drugs. This review article highlights recent advances in nanofiber-based delivery of small molecules for musculoskeletal regenerative engineering. The article concludes with perspectives on the challenges and future directions.
In this review, advances in nanofiber-based delivery of small molecules are discussed from the standpoint of their potential role in musculoskeletal regenerative engineering, highlighting both future directions and current challenges.
将小型生物活性分子与先进材料相结合的肌肉骨骼再生工程方法，已成为肌肉骨骼修复与再生极具前景的策略。先进的生物材料技术已揭示，用于肌肉骨骼组织工程的基于纳米纤维的支架可作为小分子药物控释的载体。这篇综述文章重点介绍了基于纳米纤维的小分子递送在肌肉骨骼再生工程方面的最新进展。文章最后展望了挑战与未来方向。
在本综述中，从小分子基于纳米纤维的递送在肌肉骨骼再生工程中的潜在作用角度进行了讨论，突出了未来方向和当前挑战。
